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Dr. Casey Platnich

Assistant Professor (Chemistry)
      
Profile Photo

Dr. Casey Platnich

Assistant Professor (Chemistry)

 CASEY.PLATNICH@tcd.ie

 


Casey Platnich is an Assistant Professor in Physical Chemistry. Casey's research interests lie at the intersection of single-molecule biophysics and DNA/RNA nanotechnology. The Platnich Lab leverages ideas from these two fields to develop new, quantitative biosensing modalities with low detection limits, for example for RNA viruses.
  Analytical chemistry   Biomolecules, Bioplastics, Biopolymers   Chemical Biology   Drug development and evaluation   Nano Biotechnology   Nanochemistry   Nanotechnology   New materials, supramolecular structures
Project Title
 DNA Hard-Drives for Digital Information Storage at the Molecular Level
From
October 2021
To
August 2025
Summary
Funding Agency
Herchel Smith Fund
Project Type
Postdoctoral Fellowship
Person Months
48

Details Date
Peer reviewer for Nature Nanotechnology, JACS, Angewandte, Science Advances, Small, etc.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Fluent Fluent Fluent
Details Date From Date To
Member of the Royal Society of Chemistry (MRSC) May 2 2026
Member of the Biochemical Society October 2025
Thieme T Schmidt, Max K Earle, Gerardo Patiño"Guillén, Yunxuan Li, Raluca"Elena Alexii, Jeremy J Baumberg, Ulrich F Keyser, Casey M Platnich, Supramolecular Interactions Modulate RNA: DNA Folding Observed via Nanopore Sensing, Angewandte Chemie, 2025, pe202508917 , Journal Article, PUBLISHED
Li, Yunxuan, Meng, Siong Chen, Wang, Yesheng, Platnich, Casey M., Earle, Max K., Mylona, Elli, Naydenova, Plamena, Baker, Stephen, Zhu, Jinbo, Keyser, Ulrich F., Nanopore detection of single-nucleotide RNA mutations and modifications with programmable nanolatches, Nature Nanotechnology, 20, (10), 2025, p1473-1481 , Journal Article, PUBLISHED  DOI
Earle, Max K., Alawami, Mohammed, Alexii, Raluca-Elena, Brauburger, Simon, Keyser, Ulrich F., Platnich, Casey M., Quantifying RNA Degradation with Single-Molecule Nanopore Sensing, Analytical Chemistry, 97, (43), 2025, p23841-23847 , Journal Article, PUBLISHED  DOI
Islas, Patricia, Platnich, Casey M., Gidi, Yasser, Karimi, Ryan, Ginot, Lorianne, Saliba, Daniel, Luo, Xin, Cosa, Gonzalo, Sleiman, Hanadi F., Automated Synthesis of DNA Nanostructures, Advanced Materials, 36, (36), 2024, Journal Article, PUBLISHED  DOI
Dore, Michael D., Rafique, Muhammad Ghufran, Yang, Tianxiao Peter, Zorman, Marlo, Platnich, Casey M., Xu, Pengfei, Trinh, Tuan, Rizzuto, Felix J., Cosa, Gonzalo, Li, Jianing, Guarné, Alba, Sleiman, Hanadi F., Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly, Nature Communications, 15, (1), 2024, Journal Article, PUBLISHED  DOI
Platnich, Casey M., Earle, Max K., Keyser, Ulrich F., Chemical Annealing Restructures RNA for Nanopore Detection, Journal of the American Chemical Society, 146, (19), 2024, p12919-12924 , Journal Article, PUBLISHED  DOI
Cox, Lachlan, Bai, Changzhuang, Platnich, Casey M., Rizzuto, Felix J., Divergent Polymer Superstructures from Protonated Poly(adenine) DNA and RNA, Biomacromolecules, 25, (5), 2024, p3163-3168 , Journal Article, PUBLISHED  DOI
Zheng, Fei, Alawami, Mohammed, Zhu, Jinbo, Platnich, Casey M., Sha, Jingjie, Keyser, Ulrich F., Chen, Kaikai, DNA Carrier-Assisted Molecular Ping-Pong in an Asymmetric Nanopore, Nano Letters, 23, (23), 2023, p11145-11151 , Journal Article, PUBLISHED  DOI
Andrea Doricchi, Casey M. Platnich, Andreas Gimpel, Friederikee Horn, Max Earle, German Lanzavecchia, Aitziber L. Cortajarena, Luis M. Liz-Marzán, Na Liu, Reinhard Heckel, Robert N. Grass, Roman Krahne, Ulrich F. Keyser, Denis Garoli, Emerging Approaches to DNA Data Storage: Challenges and Prospects, ACS Nano, 2022, Journal Article, PUBLISHED  DOI
Felix J. Rizzuto, Casey M. Platnich, Xin Luo, Yao Shen, Michael D. Dore, Christophe Lachance-Brais, Alba Guarné, Gonzalo Cosa, Hanadi F. Sleiman, A dissipative pathway for the structural evolution of DNA fibres, Nature Chemistry, 2021, Journal Article, PUBLISHED  DOI
  

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Award Date
University of Cambridge Herchel Smith Postdoctoral Fellowship October 2021 - August 2025
Best Early Career Researcher 2026 - Single-Molecule Sensors and NanoSystems International Conference (S3IC) January 2026
My main research interest is bringing biosensing down to the ultimate resolution of a single-molecule. The key modalities of my research group are solid-state nanopore sensing and single-molecule fluorescence microscopy. Capitalising on the self-assembly properties of DNA and RNA, I make unique nanoscale topologies capable of directly detecting biomolecules of interest, with single-molecule readout.