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Professor Mark Little

Professor/Consultant of Nephrology (Clinical Medicine)

 


  ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES   Biomarkers of disease   CRESCENTIC GLOMERULONEPHRITIS   IMMUNE-COMPLEX GLOMERULONEPHRITIS   Inflammation   MOUSE MODELS   Nephrology   NEUTROPHIL ADHESION   RAT MODEL   REGISTRY   SYSTEMIC VASCULITIS   VASCULITIS
 HELICAL - Health Data Linkage for Clinical Benefit
 AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
 Urinary sCD163 as a biomarker in crescentic glomerulonephritis
 Irish Rare Kidney Disease Registry and Biobank
 The acute, untreated patient with vasculitis: enhancing recruitment and sampling using a national network

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Details Date
Autoimmune strand lead, RITA European Reference Network 1/3/17
Co-chair UKIVAS national vasculitis registry 2010
Co-chair UKIVAS, the vasculitis rare disease group of the UK and Ireland 2011
Registries lead, European Vasculitis Society 2014
Chair Irish Rare Kidney Disease Registry and Biobank 2012
Chair of Irish Nephrology Society research committee 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Fellow of Trinity College Dublin 1/5/13
Fellow of the Royal College of Physicians 2012
American Society of Nephrology 2010
The Renal Association 2008
Jayne DRW, Merkel PA, Schall TJ, Bekker P, ADVOCATE Study Group, Avacopan for the Treatment of ANCA-Associated Vasculitis., The New England journal of medicine, 2021, Journal Article, PUBLISHED  DOI
Batten I, Robinson MW, White A, Walsh C, Fazekas B, Wyse J, Buettner A, D'Arcy S, Greenan E, Murphy CC, Wigston Z, Gabhann-Dromgoole JN, Vital EM, Little MA, Bourke NM., Investigation of type I interferon responses in ANCA-associated vasculitis., Scientific reports, 11, (1), 2021, p8272 , Journal Article, PUBLISHED  DOI
Cliona Cowhig, Jennifer Scott, Anthony M Dorman, Mark A Little, Declan G de Freitas, Acute renal allograft failure in a patient with vasculitis, Rheumatology, 2021, Journal Article, PUBLISHED  DOI
McKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, Stevenson NJ, Little MA, Molloy EJ, Neutrophils: Need for Standardized Nomenclature., Frontiers in immunology, 2021, Journal Article, PUBLISHED  DOI
David R.W. Jayne and Peter A. Merkel and Thomas J. Schall and Pirow Bekker, Avacopan for the Treatment of ANCA-Associated Vasculitis, New England Journal of Medicine, 384, (7), 2021, p599--609 , Journal Article, PUBLISHED  DOI
Rutherford MA, Scott J, Karabayas M, Antonelou M, Gopaluni S, Gray D, Barrett J, Brix SR, Dhaun N, McAdoo SP, Smith RM, Geddes C, Jayne D, Luqmani R, UKIVAS, Risk factors for severe outcomes in patients with systemic vasculitis & COVID-19: a bi-national registry-based cohort study., Arthritis & rheumatology (Hoboken, N.J.), 2021, Journal Article, PUBLISHED  DOI
Moiseev S, Kronbichler A, Makarov E, Bulanov N, Crnogorac M, Direskeneli H, Galesic K, Gazel U, Geetha D, Guillevin L, Hrušková Z, Little MA, Jayne DRW, Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study., Rheumatology (Oxford, England), 2021, Journal Article, PUBLISHED  DOI
Emma Leacy, Gareth Brady, Niall Conlon, Jennifer Scott, Jean Dunne, Thomas Phelan, William J McCormack, Matthew D Griffin, Alan Kennedy, Alyssa Verrelli, Eamonn Molloy, Declan O'Sullivan, Julie Power, Michael Clarkson, Lina Zgaga, Michelle O'Saughnessy, Mark A Little, Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient, HRB Open Res, 4, (6), 2021, Journal Article, PUBLISHED  TARA - Full Text  DOI
Scott J, Hartnett J, Mockler D, Little MA., Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review., Autoimmunity reviews, 2020, p102660 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Alan D. Salama, Mark A. Little, Coaxing Anti-Inflammatory Granulocytes to Prevent Ischemic Kidney Injury: A Fine Balance, Journal of the American Society of Nephrology, 2020, pASN.2020020146 , Journal Article, PUBLISHED  URL
  

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Award Date
President of Ireland Young Researchers Award 2012
I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. We are addressing the following questions: 1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis? 2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult? 3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.