Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Roisin Mc Mackin

Assistant Professor (Physiology)
BIOMEDICAL SCIENCES INSTITUTE

 mcmackro@tcd.ie

 3531896 2718


Biography

Dr Roisin McMackin was awarded a PhD in Clinical Medicine in 2021 from Trinity College Dublin for investigation of electrophysiological biomarkers of ALS. This research was undertaken at the Academic Unit of Neurology, where she subsequently continued her research postdoctorally with the support of a prestigious MNDA Non-Clinical Fellowship. Dr McMackin began her role as Assistant Professor in the Discipline of Physiology in October 2022. Dr McMackin's research is supported by the Motor Neurone Disease Association UK, The Irish Health Research Board and Research Motor Neurone, in addition to previous support from the Irish Research Council.

Research Tags

  Age related diseases   Biomedical sciences   Biostatistical methods   Clinical research, trials   Genomes, Genomics   Human genetics   Neurodegeneration   Neuropsychology

Representations

Details Date
Trinity College Dublin Representative of the Neuroscience Ireland Committee 14/08/2023

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Neuroscience Ireland 09/2022 Present
Irish Electrophysiology Research Clinic 26/05/2020 Present
McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. , Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis., Neurobiol Aging, 104, 2021, p57-70 , Notes: [doi: 10.1016/j.neurobiolaging.2021.03.002. Online ahead of print. PMID: 33964609], Journal Article, PUBLISHED
Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. , Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. , J Neurol Neurosurg Psychiatry. , 92, (5), 2021, p460-465 , Notes: [doi: 10.1136/jnnp-2020-324992. Epub 2021 Feb 9. PMID: 33563807], Journal Article, PUBLISHED  TARA - Full Text
Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, McLaughlin R, Pender N, Bede P, Muthuraman M, van den Berg L, Hardiman O, Nasseroleslami B., Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis., Brain : a journal of neurology, (awab3222), 2021, Journal Article, PUBLISHED  DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, Keenan O, Fasano A, Buxo T, Heverin M, Reilly RB, Pender N, Hardiman O, Nasseroleslami B, Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS., Journal of neural engineering, 18, (2), 2021, p026006 , Journal Article, PUBLISHED  DOI
Calvert GHM, McMackin R, Carson RG., Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 131, (11), 2020, p2551-2560 , Journal Article, PUBLISHED  DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020, Notes: [DOI: 10.1093/cercor/bhaa076], Journal Article, PUBLISHED  DOI
McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B., Neurophysiological markers of network dysfunction in neurodegenerative diseases, Neuroimage Clin, 22, 2019, p101706-, Notes: [doi: 10.1016/j.nicl.2019.101706. [Epub ahead of print] Review. PMID: 30738372], Journal Article, PUBLISHED  TARA - Full Text  URL
McMackin R, Muthuraman M, Groppa S, Babiloni C, Taylor JP, Kiernan MC, Nasseroleslami B, Hardiman O., Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis., Journal of neurology, neurosurgery, and psychiatry, 90, (9), 2019, p1011 - 1020, Notes: [DOI: 10.1136/jnnp-2018-319581], Journal Article, PUBLISHED  TARA - Full Text  DOI
Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B., Patterned functional network disruption in amyotrophic lateral sclerosis. , Human Brain Mapping, 40, (16), 2019, p4827 - 4842, Notes: [2019 Jul 26. doi: 10.1002/hbm.24740. [Epub ahead of print] PMID: 31348605 ], Journal Article, PUBLISHED  URL
McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, Muthuraman M, Hardiman O, Nasseroleslami B, Dysfunction of attention switching networks in amyotrophic lateral sclerosis. , Neuroimage Clin, 22, 2019, p101707-, Notes: [doi: 10.1016/j.nicl.2019.101707. [Epub ahead of print] PMID: 30735860], Journal Article, PUBLISHED  TARA - Full Text  DOI
  


  

Awards and Honours

Award Date
Neuroscience Ireland Early Career Investigator Award 2022
Brainbox Research Challenge Award 2020
Omniscient Neurotechnology Infinitome Imaging Award 2021
Trinity College Dublin University Gold Medal 2016
Trinity College Dublin Non-Foundation Scholarship 2014
Barbara Ryan Prize (TCD) 2015
Julian Boldy Prize (TCD) 2013
Eli Lilly Chemistry Prize 2013

Research Interests

Description Of Research Interests

Dr McMackin"s research includes the use of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to investigate neural network function in health and neurodegenerative diseases. Her research aims are (i) to improve understanding of the cellular, neurochemical and and network physiology captured by electrophysiological measurements and (ii) to use electrophysiological measurements to progress understanding of neurodegenerative disease mechanisms, to identify diagnostic and prognostic biomarkers and to improve the outcome measures used to test potential therapies in neurological clinical trials. Dr McMackin has a particular interest in amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease. Dr McMackin is also actively involved in preclinical drug development wet lab studies.