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Profile Photo

Dr. Rachel Mary Mc Loughlin

Professor in Immunology (Biochemistry)
      
Profile Photo

Dr. Rachel Mary Mc Loughlin

Professor in Immunology (Biochemistry)

 Rachel.McLoughlin@tcd.ie

 3531896 2526


  BACTERIAL INFECTION   BLOOD-STREAM INFECTIONS   CD4(+) T-CELLS   Hospital acquired infections   Human infection   HUMAN POLYMORPHONUCLEAR NEUTROPHILS   HUMAN T-CELLS   IMMUNE CELLS   IMMUNOLOGY   INFECTION   Infection and immunity   Infection Model   MONONUCLEAR-CELLS   Mucosal Immunology   STAPHYLOCOCCUS AUREUS INFECTION
Project Title
 Skin delivery and tissue-resident T cell responses: implications for innovative vaccines
From
2021
To
2025
Summary
Funding Agency
GlaxoSmithKline
Project Type
Industry Collaboration
Project Title
 Characterisation and exploitation of skin resident memory CD4 T cells for novel vaccines for Staphylococcus aureus
From
2019
To
2024
Summary
Funding Agency
GlaxoSmithKline
Project Type
Industry Collaboration
Project Title
 Vaccination:Knowledge is Power
From
2018
To
2022
Summary
Funding Agency
Health Research Board
Programme
Grant Knowledge Exchange and Dissemination (KEDS)
Project Title
 Delineating immune memory to Staphylococcus aureus
From
2018
To
2022
Summary
Funding Agency
Science Foundation Ireland
Programme
ERC Development Award
Project Title
 Staphylococcus aureus induced immunosuppressive memory: consequences for bug and for host
From
01/09/17
To
31/08/21
Summary
202846/Z/16/Z
Funding Agency
Wellcome Trust
Programme
Investigator Awards
Person Months
60

Page 1 of 4
Details Date
Member of the Welcome Immune system in health and disease discovery advisory group (2020-2024), which short list candidates for Wellcome Career development awards and Wellcome Discovery awards. The panel meets 3 times per year, reviewing 20-30 applications each time. 2020
Invited panellist- Symposium on Fundamental Biomedical Research, Royal Irish Academy. This event was organised by the Academy"s Life and Health Sciences Committee to highlight the importance of fundamental research and the success of Irish research in this area. The event aimed to demonstrate the need for increased funding for fundamental research in order to build national capacity and improve the career paths and prospects for biomedical researchers. An event report was submitted to the Public consultation on National Life Sciences Strategy https://www.ria.ie/2025/11/12/royal-irish-academy-life-and-health-science-committee-releases-two-event-reports/ 2025
Ad Hoc Reviewer- Journal of Immunology, Infection and Immunity, Cell reports, Nature Communications, PlosPathogen, Leucocyte Biology, Trends in Microbiology, Frontiers in Immunology, Journal of Clinical investigate. ~8 per year. 2011
Internal examiner for PhD thesis TCD: School of Biochemistry and Immunology (2012, 2016, 2018, 2022, 2025), School of Medicine (2024, 2025), Department of Microbiology (2023). 2012
Strategic Advisory Board Member- KLEB-GAP/NOR-KLEB The Norwegian Klebsiella pneumoniae network Funded by the Norwegian Research Council. Provide scientific oversight and assess progress of this consortium grant. 2019
Thesis advisor committee University of Zurich- Invited to serve as an external expert on a thesis advisor committee for student registered at the University of Zurich. Participate in annual online meetingd and 1 mid term in person review meeting, plus option to sit on thesis examination committee. 2026-2030
External examiner for PhD thesis: University of Rome Tor Vergata (2026), University of Hull (2025), Univeristy of Warwick (2021), The University of Sheffield (2020), Karowlinski Institute (2018),University of Ghent (2019), Queens University Belfast (2018) 2018
Ad Hoc Grant Reviewer for multiple international agencies: UKRI (BBSRC, MRC), Rosetree Trust, Lister Foundation, Swiss National Science Foundation, Pasteur Institute, Rosetrees Trust, DFG-German Research Foundation, Independent Research Fund Denmark. Approx 4 per year. 2013
Associate editor PLOS Pathogens. Since 2020 I have been an associated editor for one of the premier journals in the field. I handle ~6-8 papers a year, providing an initial review for suitability to send to external peer review and then managing the review process. 2020
Editorial board member Infection and Immunity. Handling ~4 papers per year plus regular peer review. 2019
Invited guest editor for journal Frontiers in Immunology secial collection "Community Series in Fighting an Elusive Enemy: Staphylococcus aureus and its Antibiotic Resistance, Immune-Evasion and Toxic Mechanisms" Volumes 1 & 2 Total 25 articles total views >320K. https://loop.frontiersin.org/people/100744/editorial 2021
Invited Guest Editor for Special edition of the journal Pathogens focused on "Staphylococcus aureus Infection" 10 articles, 46K views www.mdpi.com/journal/pathogens/special_issues/staphylococcus 2015
Details Date From Date To
Irish Society of Immunology 2013 to date
British Society Immunology 2010 to date
American Association of Microbiology 2011 2013
Infectious Diseases Society of America 2006 2009
American Association of Immunology 2005 2013
International Cytokine Society 2016 to date
Murphy DM, Batten I, O'Farrell A, Carlile SR, O'Rourke SA, Court C, Morris B, Leisching G, Jameson G, Connolly SA, Dyer AH, McGrath JP, McNally E, Basdeo SA, IFN-Y-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals., JCI insight, 2026, Journal Article, PUBLISHED  DOI
Dempsey DJ, Imangaliyev S, Claxton TJ, Browne E, Connolly R, Ng J, Denton M, Griffin B, Little MA, Humphreys H, White A, McLoughlin RM., Circulating T-cell phenotypes are influenced by prior Staphylococcus aureus exposure in hemodialysis patients., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026, Journal Article, PUBLISHED  DOI
Doherty, Ultán P. and McLoughlin, Rachel M. and White, Arthur, Challenges and Adaptations of Model-Based Clustering for Flow and Mass Cytometry, WIREs Computational Statistics, 17, (1), 2025, p1 - 15, Notes: [e70017 EOCS-722.R2], Journal Article, PUBLISHED  TARA - Full Text  DOI
Kelly AM, Vozza EG, Morris B, Cahill SC, Leane CM, Corr SC, McLoughlin RM., Staphylococcus aureus induces miR-21 expression to promote bacterial persistence during nasal colonisation., Clinical immunology (Orlando, Fla.), 281, 2025, p110593 , Journal Article, PUBLISHED  DOI
Cahill SC, Soldaini E, McLoughlin RM., Pathobiont immune tuning: the untold consequences of Staphylococcus aureus exposure on host immunity., Trends in microbiology, 2025, pS0966-842X(25)00219-7 , Journal Article, PUBLISHED  DOI
Ultán P. Doherty, Rachel McLoughlin, Tracey Claxton, Arthur White, gateTree: A user-informed tree algorithm for population identification in flow cytometry, International Workshop on Statistical Modelling 2024, Durham, United Kingdom, 14 to 19 July 2024, edited by Jochen Einbeck, Reza Drikvandi, Georgios Karagiannis, Konstantinos Perrakis, Qing Zhang , 2024, pp108 - 113, Conference Paper, PUBLISHED  URL
McCarthy KN, Hone S, McLoughlin RM, Mills KHG., IL-17 and IFN-producing respiratory tissue resident memory CD4"T cells persist for decades in adults immunized as children with whole cell pertussis vaccines., The Journal of infectious diseases, 230, (3), 2024, pe518"e523 , Journal Article, PUBLISHED  DOI
Kelly AM, McCarthy KN, Claxton TJ, Carlile SR, O'Brien EC, Vozza EG, Mills KH, McLoughlin RM., IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection., JCI insight, 9, (13), 2024, pe178216 , Journal Article, PUBLISHED  DOI
Clowry Juliann, Dempsey Daniel J, Claxton Tracey J, Towell Aisling M, Turley Mary B, Sutton Marti, Geoghegan Joan A, Kezic Sanj, Jakasa Ivon, White Arthu, Irvine Alan D, McLoughlin Rachel M, Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis, 9, (9), 2024, p1-19 , Journal Article, PUBLISHED  DOI  URL
Carlile, S.R. and Cahill, S.C. and O'Brien, E.C. and Neto, N.G.B. and Monaghan, M.G. and McLoughlin, R.M., Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection, iScience, 27, (12), 2024, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
  

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Award Date
Elected Co-Chair for Staphylococcal Disease Gordon Research Conference 2029 2025
TCD Faculty of STEM Award for Excellence in Postgraduate Research Supervision 2023
Invited to participate in St Brigid's Day Event, Irish Embassy London: Celebrating the creativity of Irish women 2018
Science Foundation Ireland Early Career Researcher of the Year 2017
Elected to Fellowship Trinity College Dublin 2016