Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Professor Martin Caffrey

Fellow Emeritus (Biochemistry)
Fellow Emeritus (Clinical Medicine)
Fellow Emeritus (School Office - Medicine)
      
Profile Photo

Professor Martin Caffrey

Fellow Emeritus (Biochemistry)

 Martin.Caffrey@tcd.ie

 

Fellow Emeritus (Clinical Medicine)

Fellow Emeritus (School Office - Medicine)


Project Title
 Structure-Function Studies of Membrane Proteins Involved in Quorum Sensing and the Pathogenicity of Pseudomonas aeruginosa
From
01/06/08
To
31/05/13
Summary
SFI: Investigatorship Award. PI, M. Caffrey. Direct costs €2,521,216.
The major goal of this project is to crystallize and to solve the X-ray structure of a select group of membrane proteins involved in quorum sensing and the pathogenicity of Pseudomonas aeruginosa. There is no overlap with the current proposal.
Funding Agency
SFI
Programme
SFI: Investigatorship Award.
Project Title
 Membrane Proteins. Crystallogenesis and X-ray Structure
From
01/09/05
To
31/08/10.
Summary
PI, M. Caffrey. Direct costs $187,500/year.
Total costs $202,500/year. Instrumentation Supplement awarded 2008, €15,000
The purpose of this project is to develop and to implement the lipidic mesophase method for membrane protein crystallogenesis.
Funding Agency
NIH
Programme
NIH: GM075915.
Project Title
 Robotic Dispensing of Cubic Phase for Crystallizing Membrane Proteins
From
7/2003
To
7/2007
Summary
Co-PI with Y. Zheng, Electrical Engineering, OSU.
Funding Agency
NSF
Programme
NSF: IIS 0308078.
Project Title
 The Structural Biology of Membrane Proteins
From
11/2003
To
05/2008
Summary
PI, M. Caffrey. . Total Award, €2.45m.
The purpose of this award was to enable the PI to establish a research program in the area of membrane structural and functional biology at The University of Limerick, Ireland. The bulk of the funding for this project was directed to equipping the lab at UL with X-ray and other biochemical/biophysical instrumentation, and to support a limited number of personnel. The University of Limerick does not have a strong tradition in fundamental research in the biosciences. The PI's charge is to contribute to getting such activity underway. His appointment at UL is strictly a research position and does not require teaching.
Funding Agency
SFI
Programme
SFI: Investigatorship Award.
Project Title
 Marie Curie. Intra European Fellowship.
From
01/05/09
To
30/04/11
Summary
€133,440.77. Postdoc funding for Dr. D. Aragao. Commission Des Communautes
Funding Agency
Marie Curie
Programme
PIEF-GA-2009-235612.

Page 1 of 6
El Ghachi, M. and Howe, N. and Huang, C.-Y. and Olieric, V. and Warshamanage, R. and Touzé, T. and Weichert, D. and Stansfeld, P.J. and Wang, M. and Kerff, F. and Caffrey, M., Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis, Nature Communications, 9, (1), 2018, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Yin, W. and Zhou, X.E. and Yang, D. and De Waal, P.W. and Wang, M. and Dai, A. and Cai, X. and Huang, C.-Y. and Liu, P. and Wang, X. and Yin, Y. and Liu, B. and Zhou, Y. and Wang, J. and Liu, H. and Caffrey, M. and Melcher, K. and Xu, Y. and Wang, M.-W. and Xu, H.E. and Jiang, Y., Crystal structure of the human 5-HT1Bserotonin receptor bound to an inverse agonist, Cell Discovery, 4, (1), 2018, p12-, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Boland C, Olatunji S, Bailey J, Howe N, Weichert D, Fetics S.K, Yu X, Merino-Gracia J, Delsaut C, Caffrey M, Membrane (and Soluble) Protein Stability and Binding Measurements in the Lipid Cubic Phase Using Label-Free Differential Scanning Fluorimetry, Analytical Chemistry, 90, (20), 2018, p12152 - 12160, Journal Article, PUBLISHED  DOI  URL
Wiktor, M. and Caffrey, M., Biophysical characterization and stabilization of detergent-solubilized lipoprotein N-acyl transferase from P. aeruginosa and E. coli, Biochimica et Biophysica Acta - Biomembranes, 1860, (6), 2018, p1384-1393 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Ghachi M.E, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez J.-C, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F, Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis, Cellular and Molecular Life Sciences, 74, (12), 2017, p2319-2332 , Journal Article, PUBLISHED  DOI  URL
Parker, J.L. and Li, C. and Brinth, A. and Wang, Z. and Vogeley, L. and Solcan, N. and Ledderboge-Vucinic, G. and Swanson, J.M.J. and Caffrey, M. and Voth, G.A. and Newstead, S., Proton movement and coupling in the POT family of peptide transporters, Proceedings of the National Academy of Sciences of the United States of America, 114, (50), 2017, p13182-13187 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Ma, P. and Weichert, D. and Aleksandrov, L.A. and Jensen, T.J. and Riordan, J.R. and Liu, X. and Kobilka, B.K. and Caffrey, M., The cubicon method for concentrating membrane proteins in the cubic mesophase, Nature Protocols, 12, (9), 2017, p1745-1762 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Caffrey, M. and Drew, D., Editorial overview: Membranes, Current Opinion in Structural Biology, 45, 2017, pvii-ix , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Wiktor, M. and Weichert, D. and Howe, N. and Huang, C.-Y. and Olieric, V. and Boland, C. and Bailey, J. and Vogeley, L. and Stansfeld, P.J. and Buddelmeijer, N. and Wang, M. and Caffrey, M., Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nature Communications, 8, 2017, p15952-, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Vogeley L, El Arnaout T, Bailey J, Stansfeld P.J, Boland C, Caffrey M, Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin, Science, 351, (6275), 2016, p876 - 880, Notes: [Cited By :5 Export Date: 7 March 2017], Journal Article, PUBLISHED  DOI  URL
  

Page 1 of 17