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Dr. Gina Renata Leisching

Research Assistant Professor (Trinity Translational Medicine Institute)
      
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Dr. Gina Renata Leisching

Research Assistant Professor (Trinity Translational Medicine Institute)

 GINA.LEISCHING@tcd.ie

 


I aim to be an innovator in the fields of academia and research. I have expertise in the areas of biomedical science and immunometabolism. I was born and raised in South Africa where I excelled academically, earning a Bachelor of Science degree in Human Physiology and a PhD in Physiological Sciences at Stellenbosch University. Following my studies, I began my career in academia, working as a postdoctoral researcher at the University of Stellenbosch in South Africa. Here, I conducted noteworthy research on tuberculosis, focusing on identifying host defense mechanisms through my studies of the bacterial molecular mechanisms that promote survival in the host cell. My research resulted in several high-impact publications in major scientific journals and has contributed significantly to our understanding of the disease. I am currently a Research Assistant Professor at Trinity College Dublin where my work aims to understand the immunometabolism of diseases underpinned by type I interferons. Currently, I have a specific interest in lupus and in identifying ways in which we can manipulate immune cell metabolism to minimise disease burden. I am passionate about contributing to the growth and development of the next generation of scientists aiming to provide them with the scientific tools to excel in their careers. My contributions to science have been widely recognized, and I have received numerous awards and accolades for my accomplishments. I was awarded a Y rating from the National Research Foundation in 2019 as a Promising Young Researcher as well as a Top 20 Postdoctoral Fellow at Stellenbosch University in 2019. I remain committed to pushing the boundaries of science and innovation, and to making a positive impact on society.
  Chronic inflamation   Health outcomes   Host, Pathogen interactions   Immune system   Inflammation and coagulation syndromes   Innate immunology
Anjali S Yennemadi, Joseph Keane, Gina Leisching, The Isolation and Characterization of Low-and Normal-Density Neutrophils from Whole Blood, Journal of Visualized Experiments (JoVE), (216), 2025, pe67805-, Journal Article, PUBLISHED  DOI  URL
Yennemadi A, Mitochondrial Bioenergetic Failure in SLE Immunocytes: Targeting Fitness for Therapy, Clinical Immunology, 2025, Journal Article, PUBLISHED
Yennemadi AS, Mitochondrial bioenergetic failure in SLE immunocytes: Targeting fitness for therapy, Clinical Immunology, 2025, Notes: [10.1016/j.clim.2025.110571], Journal Article, PUBLISHED  DOI
Kevin Brown, Aaron M. Walsh, Anjali S Yennemadi, Dearbhla M Murphy, Sarah Conolly, Mary P. O"Sullivan, Sharee A. Basdeo, Seónadh M. O"Leary, Gina Leisching, Joseph Keane, HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis, 2025, Journal Article, PUBLISHED  DOI
Lorraine Thong, Olivia Sandby Thomas, Oisin Ó Gallchobhair, Emily Duffin, Anjali S Yennemadi, Gina Leisching, Dearbhla M Murphy, Parthiban Nadarajan, Fiona O" Connell, M. Sullivan, Sharee A. Basdeo, Donal J Cox, Joseph Keane, Dexamethasone impairs glycolysis but improves mycobacterial killing in primary human macrophages, 2025, Journal Article, PUBLISHED  DOI
Seán Donohue, Gina Leisching, Joseph Keane, The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis, The Journal of Infectious Diseases, 2025, Journal Article, PUBLISHED  DOI
Anjali S Yennemadi, Faye K Murphy, Joseph Keane, Gina Leisching, Sex-Specific Metabolic Programming in Human Neutrophil Subsets, 2025, Journal Article, PUBLISHED  DOI
Faye K Murphy, Anjali S Yennemadi, Natasha Jordan, Gina Leisching, The role of interferon-mediated suppression of monocyte immunothrombosis in infection susceptibility in systemic lupus erythematosus, Clinical & Experimental Immunology, 220, (1), 2025, Journal Article, PUBLISHED  DOI
Gina Leisching, Donal J Cox, Vincent Bondet, Anjali S Yennemadi, Seán Donohue, Darragh Duffy, Joseph Keane, Human macrophages secrete both interferon " and interferon ß protein during infection with Mycobacterium tuberculosis, 2025, Journal Article, PUBLISHED  DOI
Anjali S Yennemadi, Natasha Jordan, Sophie Diong, Joseph Keane, Gina Leisching, The Link Between Dysregulated Immunometabolism and Vascular Damage: Implications for the Development of Atherosclerosis in Systemic Lupus Erythematosus and Other Rheumatic Diseases, The Journal of Rheumatology, 2024, Journal Article, PUBLISHED  URL
  

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Award Date
Health Research Board Emerging Investigator Award 2024
Promising Young Researcher (National Research Foundation) 2019
Top 20 Post-doctoral Fellow (stellenbosch University, South Africa) 2019
My research interests include immunopathological mechanisms related to cellular metabolism in both SLE and TB. I aim to conduct patient-centered research with outcomes being relevant to patients and their families. I am particularly interested in thromboinflammation and the immune-related pathways driving this phenomenon in disease.