Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Gina Renata Leisching

Research Assistant Professor (Trinity Translational Medicine Institute)
      
Profile Photo

Dr. Gina Renata Leisching

Research Assistant Professor (Trinity Translational Medicine Institute)

 GINA.LEISCHING@tcd.ie

 


I aim to be an innovator in the fields of academia and research. I have expertise in the areas of biomedical science and immunometabolism. I was born and raised in South Africa where I excelled academically, earning a Bachelor of Science degree in Human Physiology and a PhD in Physiological Sciences at Stellenbosch University. Following my studies, I began my career in academia, working as a postdoctoral researcher at the University of Stellenbosch in South Africa. Here, I conducted noteworthy research on tuberculosis, focusing on identifying host defense mechanisms through my studies of the bacterial molecular mechanisms that promote survival in the host cell. My research resulted in several high-impact publications in major scientific journals and has contributed significantly to our understanding of the disease. I am currently a Research Assistant Professor at Trinity College Dublin where my work aims to understand the immunometabolism of diseases underpinned by type I interferons. Currently, I have a specific interest in lupus and in identifying ways in which we can manipulate immune cell metabolism to minimise disease burden. I am passionate about contributing to the growth and development of the next generation of scientists aiming to provide them with the scientific tools to excel in their careers. My contributions to science have been widely recognized, and I have received numerous awards and accolades for my accomplishments. I was awarded a Y rating from the National Research Foundation in 2019 as a Promising Young Researcher as well as a Top 20 Postdoctoral Fellow at Stellenbosch University in 2019. I remain committed to pushing the boundaries of science and innovation, and to making a positive impact on society.
  Chronic inflamation   Health outcomes   Host, Pathogen interactions   Immune system   Inflammation and coagulation syndromes   Innate immunology
Anjali S Yennemadi, Joseph Keane, Gina Leisching, The Isolation and Characterization of Low-and Normal-Density Neutrophils from Whole Blood, Journal of Visualized Experiments (JoVE), (216), 2025, pe67805-, Journal Article, PUBLISHED  URL
Anjali S Yennemadi, Natasha Jordan, Sophie Diong, Joseph Keane, Gina Leisching, The Link Between Dysregulated Immunometabolism and Vascular Damage: Implications for the Development of Atherosclerosis in Systemic Lupus Erythematosus and Other Rheumatic Diseases, The Journal of Rheumatology, 2024, Journal Article, PUBLISHED  URL
Leisching G, Yennemadi A, Gogan K, Keane J., Interferon " and ß induce differential transcriptional and functional metabolic phenotypes in human macrophages and blunt glycolysis in response to antigenic stimuli., European journal of immunology, 2024, pe2451032 , Journal Article, PUBLISHED  DOI
Anjali S. Yennemadi, Joseph Keane, Gina Leisching, Mitochondrial bioenergetic changes in systemic lupus erythematosus immune cell subsets: Contributions to pathogenesis and clinical applications, Lupus, 2023, p096120332311646 , Journal Article, PUBLISHED  DOI
Yennemadi AS, Jameson G, Glass M, De Pasquale C, Keane J, Bianchi M, Leisching G., Chronic IFN" treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring., Cellular immunology, 390, 2023, p104741 , Journal Article, PUBLISHED  DOI
Cilian Ó Maoldomhnaigh, Donal J Cox, James Joseph Phelan, Karl M. Gogan, Kate McQuaid, Amy Martina Coleman, Sharee Ann Basdeo and Joseph Keane., Lactate alters metabolism in human macrophages and improves their ability to kill Mycobacterium tuberculosis, Frontiers in Immunology, 2021, Journal Article, PUBLISHED
Abhilasha Madhvi, Hridesh Mishra, Novel N. Chegou, Gerard Tromp, Carel J. Van Heerden, R. D. Pietersen, Gina Leisching, Bienyameen Baker, Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study, Virulence, 11, (1), 2020, p170--182 , Journal Article, PUBLISHED  DOI
Leisching G, Keane J., Bystander Macrophage Metabolic Shift after Mycobacterium tuberculosis Infection., American journal of respiratory cell and molecular biology, 63, (6), 2020, p863-865 , Journal Article, PUBLISHED  DOI
Dannielle K Moore, Gina R. Leisching, Candice I. Snyders, Andrea Gutschmidt, Ilana C. Rensburg, Andre Loxton, Immunoglobulin profile and B"cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions, Immunity, Inflammation and Disease, 8, (3), 2020, p458--467 , Journal Article, PUBLISHED  DOI
Abhilasha Madhvi, Hridesh Mishra, GR Leisching, PZ Mahlobo, B Baker, Comparison of human monocyte derived macrophages and THP1-like macrophages as in vitro models for M. tuberculosis infection, Comparative Immunology, Microbiology and Infectious Diseases, 67, 2019, p101355 , Journal Article, PUBLISHED  DOI
  

Page 1 of 3

  


Award Date
Health Research Board Emerging Investigator Award 2024
Promising Young Researcher (National Research Foundation) 2019
Top 20 Post-doctoral Fellow (stellenbosch University, South Africa) 2019
My research interests include immunopathological mechanisms related to cellular metabolism in both SLE and TB. I aim to conduct patient-centered research with outcomes being relevant to patients and their families. I am particularly interested in thromboinflammation and the immune-related pathways driving this phenomenon in disease.