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Dr. Denis Barry

Assistant Professor (Anatomy)
BIOMEDICAL SCIENCES INSTITUTE


I was awarded a PhD in neuroscience from the Department of Anatomy and Neuroscience, University College Cork in 2005. I subsequently conducted postdoctoral research into genetic brain disorders at the Department of Pathology and Cell Biology, Columbia University, New York. From 2008 until 2011, I undertook postdoctoral research fellowship positions focusing on HIV-1 pathogenesis and cardiovascular diseases at the Centre for Research into Infectious Diseases and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin. In 2011, I was appointed to the position of Lecturer/Principle Investigator in the Department of Anatomy and Neuroscience, University College Cork. In 2013, I was appointed to the position of Assistant Professor in the Department of Anatomy, School of Medicine, TCD. In 2021, I was appointed to the position of Head of Discipline of Anatomy, School of Medicine, TCD.
Details Date From Date To
Anatomical Society of Great Britain and Ireland 2013 Ongoing
Royal Microscopy Society 2014 Ongoing
Mohammad Alherz, David Lee, Amnah Alshangiti ,Darren Roddy, Gerard O'Keeffe, Robin White and Denis Barry, The growth response to beta-hydroxybutyrate in SH-SY5Y neuroblastoma cells is masked by glucose and pyruvate supplementation, Neurochemical Research, 2021, Journal Article, PUBLISHED  DOI  URL
JW Power, PJ Dempsey, D Barry, G Slater, J McMenamin and M McNicholas, Radiology Perspective on Anatomy Teaching in Australia and New Zealand, Surgical and Radiologic Anatomy, 2021, Journal Article, PUBLISHED  DOI  URL
Walid El Kininy, Darren Roddy, Shane Davy, Elena Roman, Veronica O'Keefe, Erik O'Hanlon, Leo F.A. Stassen and Denis Barry, Magnetic resonance diffusion weighted imaging using constrained spherical deconvolution-based tractography of the extracranial course of the facial nerve, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2020, Journal Article, PUBLISHED  DOI  URL
Elena Roman, Joshua Weininger, Basil Lim, Marin Roman, Denis Barry, Paul Tierney, Erik O'Hanlon, Kirk Levins, Veronica O'Keane, Darren Roddy, Untangling the dorsal diencephalic conduction system: a review of structure and function of the stria medullaris, habenula and fasciculus retrofexus, Brain Structure and Function , 2020, Journal Article, PUBLISHED  DOI  URL
Albert Kelly, Aisling O'Malley, Mohammad Redha, Gerard W. O'Keeffe and Denis S. Barry, The distribution of the proteoglycan FORSE-1 in the developing mouse central nervous system, Journal of Anatomy, 234, (2), 2019, p216 - 226, Journal Article, PUBLISHED  DOI  URL
Gerard O'Keeffe, Shane Davy and Denis Barry, Radiologist's views on anatomical knowledge amongst junior doctors and the teaching of anatomy in medical curricula, Annals of Anatomy, 2019, Journal Article, PUBLISHED  DOI  URL
Jonathon Jeger, Trinity Kronk and Denis Barry , Feasacht Sláinte: Irish Medical Students' Perspective on the Importance of Anatomy and Physiology for the Irish Public, Irish Medical Journal, 112, (6), 2019, Journal Article, PUBLISHED  URL
Danya Stone and Denis Barry, Improving Virtual Learning Interactions: Reducing Transactional Distance Through Social Media Platforms, Anatomical Sciences Education, 2019, Journal Article, PUBLISHED  DOI  URL
Dervla O'Malley, Denis S. Barry and Mark G. Rae, How much do pre-clinical medical students utilise the internet to study physiology?", ADV-00070-2019R2 to be considered for publication in Advances in Physiology Education, Advances in Physiology Education, 43, (3), 2019, p383 - 391, Journal Article, PUBLISHED  DOI  URL
Kirk J. Levins, Thomas Drago, Elena Roman, Anna Martin, Roisin King, Paul Murphy, Hugh Gallagher, Denis Barry, Erik O'Hanlon & Darren William Roddy, Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients, Systematic reviews, 8, (338), 2019, Journal Article, PUBLISHED  DOI  URL
  

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Kirk J. Levins, Thomas Drago, Elena Roman, Anna Martin, Roisin King, Paul Murphy, Hugh Gallagher, Denis Barry, Erik O'Hanlon & Darren William Roddy, Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients, Systematic reviews, 8, (338), 2019, Journal Article, PUBLISHED
Kirk Levins, Elena Roman, Hugh Gallagher, Paul Murphy, Patrick O'Regan, Denis Barry, Veronica O'Keane, Erik O'Hanlon, Darren Roddy, A diffusion Tensor Protocol for the Stira Medullaris in Chronic Pain Patients, Pain Medicine, American Academy of Physicists in Medicine, Alexandria, VA, November 2 - 3, 2018, 20, (3), 2019, pp583 - 660, Meeting Abstract, PUBLISHED
Dervla O'Malley, Denis S. Barry and Mark G. Rae, The increasing reliance of pre-clinical medical students upon social media to study physiology, EdTech, Dundalk IT, May 30-31st, 2019, 2019, Meeting Abstract, ACCEPTED
Elena Roman, Bernard Adegbemi, Roisin King, Caoimhe Gaughan, Anurag Nasa, Kirk Levins, Denis Barry, Veronica O'Keane, Darren William Roddy, Erik O'Hanlon, Hippocampal substructural changes over the normal lifespan, Anatomical Society Summer Meeting, Oxford, 2018, Meeting Abstract, PRESENTED
JW Power, P Dempsey, D Barry, S Davy, G Slater, MMJ McNicholas, Radiology in Anatomy Undergraduate Teaching in Australia and New Zealand, Annual Scientific Meeting Faculty of Radiologists, Dublin RCSI, 23-25th September, 2018, Meeting Abstract, PRESENTED
Alannah Grealy, Eilidh Murphy, Joshua Weininger, Marissa Malkit, Elena Roman, Kirk Levins, Denis Barry, Veronica O'Keane, Erik O'Hanlon, Darren William Roddy, Subdivisions of the Cingulum bundle and changes with age, Anatomical Society Summer Meeting, Oxford, 23-25th July, 2018, Meeting Abstract, PUBLISHED
Joshua Weininger, Marissa Malkit, Alannah Grealy, Eilidh Murphy, Elena Roman, Kirk Levins, Denis Barry, Veronica O'Keane, Erik O'Hanlon, Darren William Roddy. , The Human Thalamocingulate Tract - controversy over its anatomical course, Anatomical Society Summer Meeting, Oxford, 23-25th July, 2018, Meeting Abstract, PRESENTED
Caoimhe Gaughan*, Anurag Nasa*, Bernard Adegbemi, Roisin King, Elena Roman, Kirk Levins, Denis Barry, Veronica O'Keane, Darren William Roddy, Erik O'Hanlon, The human dorsal hippocampal commissure: untangling its connections , Journal of Anatomy, Anatomical Society Summer Meeting, Oxford, 23-25th July, 2018, Meeting Abstract, PRESENTED
Dervla O'Malley, Denis S. Barry and Mark G. Rae, How much do pre-clinical medical students utilise the internet to study physiology?, Europhysiology, London, 14-16 September, 2018, Meeting Abstract, PRESENTED
El Kininy W, Roddy D, Davy S, O'Keane V, O'Hanlon E, Stassen LFA & Barry D, 3-Dimensional tractography of the extracranial facial nerve course using diffusion weighted Magnetic Resonance Imaging, Anatomical Society Winter Meeting, Dundee, 18-20th Dec 2017, 2018, Oral Presentation, PRESENTED

  

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Award Date
SATLE Award: National Forum for the Enhancement of Teaching and Learning (National Forum) 2021
SpCert Academic Practice 2020
Deans Award for Teaching in Innovation 2018
Wellcome Trust Biomedical Vacation Scholarship 2017
Anatomical Society Summer Vacation Student Scholarship 2017
Article selected as one of ten most influential Anatomical Sciences Education 2019
Nominated Provost Teaching Award 2013
My main research focuses on the lineages, functions and restorative potential of neural precursor cells. Radial glial cells are elongated neural progenitor cells present in the CNS during development that represent a major progenitor pool during development and can give rise to neurogenic niches of the adult. I have shown that radial glial cells are essential for correct white matter formation in the spinal cord forming glial scaffolds that guide growing axons to their synaptic destinations. A primary research goal is gaining insights into the potentials of radial glial cells, and their axon scaffolding properties, in restoring connectivity in the spinal cord using an in vitro injury model. Three dimensional imaging, using new methods such as 3DISCO, of these scaffolds should enhance our understanding of the axon-glial interactions occurring within them. We aim to rigorously characterise these scaffolds and the biomarkers they express to shed light on their potentials in restoring tract formation in injury scenarios. As such, biomarkers such as proteoglycans are also showing much potential in identifying subsets of neural cells that are responsible for mediating tract formation and for determining the fates of multipotent stem cells. Glycans regulate the activity of membrane receptors and mediate cell-cell or cell-matrix interactions. LewisX (LeX) is a glycan motif associated with glycoproteins and glycolipids that is present on neural stem and progenitor cells and acts in association with Wnt and notch signalling. We have shown that LeX is present on discrete subpopulations of neuroepithelial and radial glial cells in the developing brain and spinal cord. However, while glycoconjugates are expected to play significant roles in stem cell therapies, the basic functional relevance of LeX glycosylated neuroepithelial cells and radial glial cells is unknown in the developing CNS.My interest in the developmental origins of brain cells is forming the basis for research linking dietary influences, such as the ketone diet (KD), to neural stem cell functions during pregnancy. The KD (low carbohydrates/ high fat) have become popular recently due to their effectiveness for weight loss and in treatment of neurological disorders such as epilepsy. Although the diet is a promising alternative to medication for those suffering from epilepsy, there is limited information about how the diet affects normal brain functioning. Furthermore, there is very little research on how KD during pregnancy may affect the developing brain. This research question becomes increasingly important as women of reproductive age may be on the diet for extended periods of time. Anatomy based research interests include the investigation of the use of Diffusion Weighted-MR Imaging (DW-MRI) for white matter tracts in vivo. Concerns remain about the robustness and anatomical relevance of this DW-MRI in probing more convoluted tracts as in the limbic system. Complex white matter architecture (crossing fibres) and methodological constraints (signal to noise ratio (SNR) and b-values become a significant issue in tract generation affecting the accuracy of the tract formations. In collaboration with investigators at TCD, I am comparing the validity of the rendered limbic white matter tracts using advanced tractography techniques to "gold standard" anatomical cadaveric dissection measurements. The goal is to reveal limbic connectivity in higher detail than has been previously described.Moreover, I am currently supervising MD research aiming to provide greater insights into the spatial relationships between the facial nerve and retromandibular vein in human cadaveric parotid glands. This research is especially significant in the context of parotid surgery. I also conduct education research based on the roles of social media in anatomy education and the insights of radiologists and surgeons on the most efficient modes of anatomy training for professional practice.