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Dr. David Coghlan

Clinical Associate Professor (Paediatrics)
Clinical Associate Professor (School Office - Medicine)
      
Profile Photo

Dr. David Coghlan

Clinical Associate Professor (Paediatrics)

 dcoghla@tcd.ie

 3531896 3763/3763

Clinical Associate Professor (School Office - Medicine)


  ACUTE CHILDHOOD ASTHMA   Allergy   Cerebral Palsy   CHILDHOOD ASTHMA   VITAMIN-D SUPPLEMENTATION
Project Title
 An RCT of Vitamin D3 in Uncontrolled Asthma
From
January 2014
To
January 2015
Summary
A double-blind, randomized, PL-controlled trial of vitamin D supplementation (2000 IU/day) in 44 urban, caucasian children at high latitude. Conclusion: Vitamin D3 supplementation led to a significant increase in serum 25(OH)D and decreased school days missed (p = 0.04), but no other advantageous changes in asthma parameters compared with PL.The potential negative effect of high serum 25(OH)D on pulmonary function warrant further investigation.
Funding Agency
National Children's Hospital Foundation
Project Type
RCT
Person Months
12
Project Title
 Protocol for Investigation of Penicillin Allergy.
From
April 2012
To
April 2013
Summary
Feasibility Study to Implement National Protocol for Investigation of Penicillin Allergy in children
Funding Agency
The National Children's Hospital Foundation
Person Months
24
Project Title
 An RCT of Vitamin D3 in Paediatric Autism
From
Jan 2015
To
Jan 2016
Summary
A double-blind, randomised, placebo-controlled trial set in a paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). Conclusion: Vitamin D supplementation had no effect on the primary outcome with limited and inconsistent effects in children with ASD. Considering the other promising data as well as the relative safety and cheapness of vitamin D supplementation, further trials are warranted.
Funding Agency
The National Children's Hospital Foundation
Project Type
RCT
Person Months
12
Project Title
 PROSPER: PaediatRic Outcomes and Serum biomarker Panel in acutE traumatic bRain injury /concussion to severe traumatic 2015-9.
From
2016
To
2019
Summary
To describe the demographics and aetiology of traumatic brain injury presenting to Irish Paediatric Emergency Departments. Concussion and mild traumatic brain injury (mTBI) are interchangeable terms.Post-concussion syndrome (PCS) occurs in 1/7 children sustaining a mTBI.Secondly to describe physician competence in this condition and to develop a best practice guideline. To elucidate biomarkers from the innate immune system that are activated in acute brain injury. Findings include preschool children have the highest incidence of head injury, mostly following a fall. There was a paucity of knowledge among all grades of medical professionals in how to manage these children. Many patients had a raised white cell count with neutrophilia. Surprisingly CD 11b neutrophil expression was not raised in mTBI on flow cytometry, but was markedly raised in the 4 most severe TBI patients.
Funding Agency
National Children's Hospital Foundation
Project Type
Prospective/Translational
Person Months
36
Project Title
 PRISM: PReterm Infection and SysteMic inflammation and neonatal outcomes.
From
2016
To
2019
Summary
This research aims to improve the understanding of the systemic inflammatory response in preterm infants and the potential for newer adjunctive therapies. In addition trying to identify immune markers that will assist in the prognosis and clinical outcomes of these preterm infants.
Funding Agency
The National Children's Hospital Foundation and Trinity College Dublin
Project Type
Prospective/Translational

Page 1 of 2
Details Date
HSE-Acute Floor Implementation Process Group( Paediatric Representative) 2018
National Electronic Health Record (EHR) Programme. Paediatric EHR Working Group 2018
Paediatric Clinical Advisor, Coeliac Society of Ireland 2018
Chair, National Guideline Committee -Management of Urinary Tract Infection in children 2015
Paediatric expert reviewer for Irish Medical Council 2016
Expert external case reviewer supporting Director Of Quality, CHI (Children's Hospital Ireland) 2018
Reviewer for Irish Medical Journal 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
FRCPI-Fellow of the Royal College of Physicians, Ireland 2002 2019
FRCPCH (UK)-Fellow of the Royal College of Physicians and Child Health 2003 2019
GAPRUKI Collaboration-General and Adolescent Paediatrics UK and Ireland Member(Research Collaboration Body) -Founding member 2016 2019
Faculty of Paediatrics, RCPI 2006 2019
ERS-European Respiratory Society Member 2003 2019
EAACI, European Academy of Allergy and Immunology, Member 2007 2019
MPS-Medical Protection Society Member 1993 2019
Irish Paediatric Surveillance Unit (IPSU) 2003 2019
British Paediatric Surveillance Unit (BPSU) 2003 2019
Coghlan D, Priorities for child health research across the UK and Ireland. , Archives ofr Disease in Childhood, 107, (5), 2022, p474 - 478, Notes: [10.1136/archdischild-2021-322636], Journal Article, PUBLISHED  DOI
Coghlan D, Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital, Archives of Disease in Childhood, 2021, Journal Article, PUBLISHED  DOI
Byrne AM, Trujillo J, Fitzsimons j... Coghlan D., Mass food challenges in a vacant COVID-19 stepdown facility: Exceptional opportunity provides a model for the future, Pediatr Allergy Immunol. 2021, 2021, Journal Article, PUBLISHED  DOI  URL
D. Coghlan, U. Murtagh, M. Nadeem, Integration of Two Acute Paediatric Services During COVID-19, Ir Med J, 114, (4), 2021, p324 , Journal Article, PUBLISHED  URL
Coghlan D, What does 'PEWing' or 'PEWsing' mean? A new word in paediatrics. Diskin C, MacDonell R, Whelan B, O' Shea O, Fitzsimons JJ, Vaughan D, Coghlan D. Arch Dis Child. 2020 May;105(5):518-519. doi: 10.1136/archdischild-2019-318252. Epub 2019 Nov 20, Achives of Disease in Childhood, (105(5):), 2020, p518 - 519, Journal Article, PUBLISHED  URL
C Howard, WL Macken, A Connolly, M Keegan, D Coghlan, DW Webb, Percutaneous endoscopic gastrostomy for refractory epilepsy and medication refusal, Arch Dis Child, 2019, Journal Article, PUBLISHED  DOI
Kerley CP, Elnazir B, Greally P, Coghlan D. , Blunted serum 25(OH)D response to vitamin D3 supplementation in children with autism, Nutr Neurosci. , 2018, Journal Article, PUBLISHED  DOI
Hutchinson K, Kerley CP, Faul J, Greally P, Coghlan D, Louw M, Elnazir B, Rochev Y. , Vitamin D receptor variants and uncontrolled asthma , Eur Ann Allergy Clin Immunol. 2018 , 2018, Journal Article, PUBLISHED  DOI
Rutledge E, Whitla L, Coghlan D, Nadeem M, Peripheral White Blood Cell Differential Counts In Children With UTI, Is There A Link?, Irish Medical Journal, 111, (6), 2018, Journal Article, PUBLISHED  URL
Khan N, Whitla L, Kenosi M, Coghlan D, Nadeem M, Follow up chest radiography in paediatric pneumonia: is it avoidable? , Irish Medical Journal, 2018, Journal Article, PUBLISHED  URL  URL
  

Page 1 of 5
A Alshahrabally D Coghlan S Quinn, Neurofibromatosis Type 1 and Crohns Disease association, Arch Gastroenterology Research, 4, (1), 2023, p1 - 3, Journal Article, PUBLISHED
J Dinsmore, E Williams, H McCarthy, D Coghlan Journal of Human Nutrition and Dietetics 24 (3), 280-281, A pilot study to explore factors affecting faltering growth in children , Journal of Human Nutrition and Dietetics 24 (3), 280-281, 2011, Journal Article, PUBLISHED

  


Award Date
Irish Paediatric Association (IPA)- Best Oral Presentation WIGUAM Study 2017
IPA-Best Poster "FPIES in infancy" 2015
Paediatrician of the Year-Laya Healthcare Awards 2015
General Paediatrics is an acute specialty caring for the undifferentiated child. It is an emerging academic specialty with a focus on clinical research and quality improvement. Since my time as a fellow at RCH Melbourne I concentrated on early child development and how clinicians and parents must collaborate to define a child's abilities in the home, school and play settings. This work included those with developmental delay and those with more severe disabilities such as cerebral palsy. More recent work has focused on interventions including Vitamin D supplementation to improve symptoms in children with Autism and Asthma. While adequate nutrition is essential many child still require daily medication and my work has also looked at improving methods of medication administration in those with acute infection, allergy and complex needs. A novel method of delivering anti-epileptic method through a feeding tube was described with great benefits for children with complex needs. Randomised Controlled trials: 1. RCT of Vitamin D supplementation in autism spectrum disorder. Randomised 42 children to receive 2000 IU Vitamin D3 daily or placebo over 20 weeks. Vitamin D had no effect on primary outcome of reducing stereotypic autistic behaviours. Trend towards reduced inappropriate speech in the Vitamin D3 treatment group. 2. RCT of Vitamin D supplementation in uncontrolled asthma. Randomised 44 children with uncontrolled asthma to receive 2000 IU Vitamin D3 or placebo over 15 weeks. Vitamin D had no effect on primary outcome of improved subjective asthma control or Fev1 on spirometry. There was a non significant improvement in Fev1 within the placebo group. 3. EVITA Trial (NIHR UK) 2024. A 3 way trial exploring equipoise between intravenous magnesium sulphate, salbutamol, and aminophyllin in children with severe acute asthma. Awaits funding Finally we've explored variation in medication response by examining genetic variants in asthma. An association was found between Taql (exon 9) and Apal (intron 8) polymorphisms and asthma risk. IL10 levels were lower in asthmatic children with Taql polymorphisms. I've also developed national guidelines published as the WIGUAM Study (Working to Implement National Guidelines for Urine Tract Infection Assessment and Management ).