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Dr. Ronan O'Toole

Visiting Research Fellow (School of Nursing & Midwifery)
      
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Dr. Ronan O'Toole

Visiting Research Fellow (School of Nursing & Midwifery)

 otooler3@tcd.ie

 


  Epidemiology   Health status and inequalities   Infectious Diseases
Project Title
 Determination of phylogenetic lineages of Mycobacterium tuberculosis isolates in New Zealand
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Summary
The objective of the project is to determine the genetic lineages of Mycobacterium tuberculosis present in New Zealand using SNP, LSP and MIRU-24 analyses and to relate the lineage data to transmission, patient demographics, and disease phenotypes. The project is being conducted in collaboration with Dr. Joshua Freeman and Dr. Indira Basu (Auckland City Hospital), and Dr. James Bower (LabPLUS, Auckland District Health Board).
Project Title
 Synthetic gene array analysis for determining the mode of action of unique tuberculosis drugs
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Summary
For the determination of specific cellular pathways targeted by candidate drugs, the applicant has conducted global transposon mutagenesis in Mycobacterium smegmatis. The mutant library has been utilised for the identification of suppressor and enhancer mutations which modulate susceptibility to anti-mycobacterial inhibitors. These data provide information on the mode of action of tuberculosis lead compounds. This project is being conducted in collaboration with Prof. Greg Cook (University of Otago).

Ronan F. O'Toole; Vitalie Covalciuc; Ana Cooke; Gaetan Thilliez; Emma K. Finlay; Kelvin W.C. Leong; Vanessa Farthing; Sebastiaan J. van Hal, Genomic characterisation of emerging Enterococcus faecium vanA types from 2013 to 2020 in an Australian public hospital, Journal of Global Antimicrobial Resistance, 2025, Journal Article, PUBLISHED  DOI
Ronan F. O'Toole, Vancomycin-resistant Enterococcus faecium and its shifting clonal types, Journal of Global Antimicrobial Resistance, 2025, Journal Article, PUBLISHED  DOI
Cian Ennis; Gaetan Thilliez; Ronan F. O'Toole, Geogenomic mapping of drug-resistant Mycobacterium tuberculosis from Ireland and overseas, 2025, Journal Article, PUBLISHED  DOI
Shakti D. Shukla; Kamal Dua; Ronan F. O"Toole, Pathogen targeting in chronic respiratory diseases: prevention, therapy and management, Frontiers in Pharmacology, 2024, Journal Article, PUBLISHED  DOI
Ronan F. O'Toole; Kelvin W.C. Leong; Vanessa Cumming; Sebastiaan J. Van Hal, Vancomycin-resistant Enterococcus faecium and the emergence of new sequence types associated with hospital infection, Research in Microbiology, 2023, Journal Article, PUBLISHED  DOI
Ronan O'Toole, Antibiotic resistance acquisition versus primary transmission in the presentation of extensively drug-resistant tuberculosis, International Journal of Mycobacteriology, 11, (4), 2022, p343 , Journal Article, PUBLISHED  DOI
Kelvin W.C. Leong and Sanjay S. Gautam and Manoj Pradhan and Y. Ibotomba Singh and K.C. Rajendra and Sagar K. Rajbhandari and Gokarna R. Ghimire and Krishna Adhikari and Uma Shrestha and Raina Chaudhary and Gyanendra Ghimire and Sundar Khadka and Ronan F. O{\textquotesingle, Comparative genomic analyses of multi-drug resistant Mycobacterium tuberculosis isolates from Nepal and other geographical locations, Genomics, 2022, p110278 , Journal Article, PUBLISHED  DOI
Understanding the Biology of Non-typeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease through the Lens of Genomics in, editor(s)Kamal Dua, Raimar Löbenberg, Ângela Cristina Malheiros Luzo, Shakti Shukla, Saurabh Satija , Targeting Cellular Signalling Pathways in Lung Diseases, Singapore, 2021, [Rajendra KC; Ronan F. O"Toole], Book Chapter, PUBLISHED  DOI
Madhur D. Shastri; Shakti Dhar Shukla; Wai Chin Chong; Rajendra KC; Kamal Dua; Rahul P. Patel; Gregory M. Peterson; Ronan F. O'Toole, Smoking and COVID-19: What we know so far, Respiratory Medicine, 2021, p106237 , Journal Article, PUBLISHED  DOI
Ronan F. O'Toole, The Interface between COVID-19 and Bacterial Healthcare-Associated Infections, Clinical Microbiology and Infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2021, Journal Article, PUBLISHED  DOI
  

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Award Date
Fellow of the Australian Society for Microbiology 2020
The primary focus of my research is the impact of communicable illnesses on vulnerable groups in society. Projects include assessing the incidence of respiratory infections in indigenous minorities and the underlying risk factors. Conditions under examination include COVID-19, tuberculosis (TB) and acute exacerbations of chronic obstructive pulmonary disease (COPD). Further research maps the acquisition and spread of multi-drug resistance (MDR) among human pathogens responsible for healthcare-associated infections (e.g. Vancomycin-Resistant Enterococci (VRE)) and community-acquired infections (e.g. MDR-TB, MDR-Salmonellosis).