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Dr. Astrid Sasse

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW

Associate Professor (Trinity Inst. of Neurosciences (TCIN))


Dr. Sasse is a certified pharmacist who obtained her PhD in Pharmaceutical Chemistry from the Free University Berlin, Germany. She conducted post-doctoral studies funded by a Marie-Curie Fellowship (FP5) at INSERM in Paris, France on the identification of a human histamine H3 receptor subtype and genetic linkage of SNPs on histamine H3 and H4 receptors to schizophrenia. As a senior staff scientist at the Max-Planck Institute for Experimental Medicine in Goettingen, Germany she determined corticotropin-releasing factor receptor binding by ex vivo autoradiography, before joining the International Center for Neurotherapeutics (ICNT) at DCU in 2004 where she was involved in the development of neurotoxins derived from botulinum toxin by protein engineering methods. In October 2008, she was appointed as Lecturer in Pharmaceutical Chemistry at the School of Pharmacy and Pharmaceutical Sciences at TCD. Her research is focused on the development of small ligands for G-Protein coupled receptors (e.g., histamine H3/H4 receptor), and the identification, localization, and pharmacological characterization of new receptor subtypes, as well as the genetic linkage of those receptors to psychiatric disorders.
  Ageing, memory and other cognitive processes   Alzheimer's disease   Analytical chemistry   Biomedical sciences   Clinical genetics   Commercialisation of scientific research   Drug development and evaluation   Drug discovery   Drug discovery, profiling, targeting   Imaging Techniques   In vitro testing, trial methods   Medicinal Chemistry   Molecular Biology   Neurochemistry and neuropharmacology   Neuroendocrinology   Neuropharmacology   Neuroscience   Protein sequence, function and expression   Proteins, enzymology and protein engineering   Schizophrenia   Spectroscopy   Synthesis and new molecules
 Recent Advances in Histamine H4 Research
 Identifying novel therapeutic targets for patients carrying single nucleotide polymorphisms in schizophrenia

Details Date
European Histamine Research Society (EHRS) Council Member 2012-
Leader of Working Group 3 of COST Action BM0806 2011-
Financial Rapporteur, COST Action BM0806 2011 -
Irish Representative, Management Committee of COST Action BM0806 'Recent Advances in Histamine Receptor H4R Research'. 2009 -
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Latin Basic Basic Basic
Details Date From Date To
PSI - Pharmaceutical Society of Ireland Sept. 2012
FENS, Federation of European Neuroscience Societies 2011
EHRS, European Histamine Research Society 2009
NI, Neuroscience Ireland 2009
SFN, Society for Neuroscience 2003
EUFEPS, European Federation for Pharmaceutical Sciences 1998
DPhG, Deutsche Pharmazeutische Gesellschaft (German Pharmaceutical Society) 1997
Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, Sadek B., Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder., Frontiers in neuroscience, 12, 2018, p304 , Journal Article, PUBLISHED  DOI
Erick Motta, Marivane Lemos, Juliana C Costa, PhD. Vilmar C Banderó-Filho.; Astrid Sasse, Helen Sheridan, Jairo K Bastos, , Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity, Chemico-Biological Interactions, 261, 2017, p145 - 155, Journal Article, PUBLISHED  DOI
Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231, Journal Article, PUBLISHED  TARA - Full Text  DOI
Fiona Shannon, Astrid Sasse, Helen Sheridan and Michael Heinrich , Are identities oral? Understanding ethnobotanical knowledge after Irish independence (1937-1939), Journal of Ethnobiology and Ethnomedicine, 13, 2017, p65-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Genetic Polymorphisms in the Histamine Receptor Family in, editor(s)Patrizio Blandina and Maria Beatrice Passani , Histamine Receptors - Preclinical and Clinical Aspects, Switzerland, Humana Press, Springer Nature, 2016, pp51 - 74, [Micallef, S and Sasse, A], Book Chapter, PUBLISHED  DOI
Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics., Carbohydrate Polymers, 123, 2015, p339 - 349, Journal Article, PUBLISHED  TARA - Full Text  DOI
Micallef S, Stark H, Sasse A, Polymorphisms and genetic linkage of histamine receptors., Life sciences, 93, (15), 2013, p487-494 , Journal Article, PUBLISHED  DOI
Sasse, A., Histamine H4R Ligand Database, Inflammation Research, 42nd Annual Meeting of the European Histamine Reserach Society (EHRS), Lodz, Poland, 8-11th May 2013, 62, (1), Springer, 2013, ppS7 - S7, Meeting Abstract, PUBLISHED  DOI
Fabio Boylan, Astrid Sasse, Helen Sheridan(ed.), Holistic Approaches to Health Maintenance in the BSc. Pharmacy Degree at Trinity College, Institute of Technology, Dundalk, Ireland, 19-20th June 2013, 2013, Notes: [CSSI - Confederation of Student Services in Ireland], Proceedings of a Conference, PRESENTED
Micallef, S, Quinn E, Morris, D, Sasse, A., MICROSATELLITE REPEAT EXPANSIONS IN HUMAN HISTAMINE(4) RECEPTOR GENE, Inflammation Reserach, 41st Annual Meeting of the European Histamine Research Society (EHRS), Belfast, Northern Ireland, UK, 2-5th May 2012, 61, (2), Springer, 2012, ppS52 - S52, Meeting Abstract, PUBLISHED  DOI
  

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The Histamine H3 Receptor: Gene Organization, Multiple Isoforms, Constitutive Activity and Molecular Pharmacology in, editor(s)Watanabe, T., Timmerman, H., Yanai, K. , Histamine Research in the New Millennium, Elsevier Science, 2001, pp9 - 21, [Arrang, J.-M., Morisset, S., Rouleau, A., Tarvidel-Lacombe, J., Gbahou, F., Ligneau, X., Héron, A., Sasse, A., Stark, H., Schunack, W., Ganellin, C.R., Schwartz, J.-C., ], Book Chapter, PUBLISHED
Partial Agonists for the Histamine H3 Receptor with High in Vivo Activity in, editor(s)Watanabe, T., Timmerman, H., Yanai, K. , Histamine Research in the New Millennium, Elsevier Science, 2001, pp77 - 82, [Schunack, W., Sasse, A., Stark, H., Elz, S., Ligneau, X., Ganellin, C.R., Schwartz, J.-C], Book Chapter, PUBLISHED

  

Award Date
Ernst-Reuter-Prize of the Free University of Berlin 2000
Carl-Wilhelm-Scheele-Prize of the German Pharmaceutical Society (DPhG) 2000
1st Poster Price during the XXIXth Annual meeting of the European Histamine Research Society (EHRS) in Nemi/Rome 2000