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Dr. Maria Santos-Martinez

Assistant Professor (Pharmacy)
25/6/7 WESTLAND ROW

Assistant Professor (Clinical Medicine)


Dr Maria J Santos-Martinez is a medical doctor Specialist in Respiratory Medicine from the Universidad Autónoma de Barcelona (Spain). She started her training as basic researcher in The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth (University of Texas Health Science-Houston-USA) in 2004. In 2006 she moved to Ireland and defended her PhD in 2009 (Trinity College Dublin). She was appointed as Assistant Professor (Ussher) in Nanopharmaceutical Drug Discovery (School of Pharmacy and Pharmaceutical Sciences & School of Medicine) in 2010.
  ANGIOGENESIS   Blood Platelets   CANCER   MATRIX METALLOPROTEINASES   Nanomedicine   nanotoxicology   Pulmonary Diseases   QUARTZ CRYSTAL MICROBALANCE
Details Date
Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Spanish Fluent Fluent Fluent
Details Date From Date To
COST Action 17140 'Cancer nanomedicine - from the bench to the bedside'(NANO2CLINIC) 2018 date
Irish Association of Pharmacologists (IAP) 2017 date
Member and co-founder of the Spanish Research Society in Ireland 2016 date
Spanish Respiratory Medicine Association (SEPAR) 2002 date
Pharmacology of Haemostasis and Thrombosis in, Velazquez Farmacologia Basica y Clinica (19th Edition) , Ed. Medica Panamericana, 2018, [Santos-Martinez MJ; Radomski MW; Medina C.], Book Chapter, PUBLISHED
Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, 1. Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection, International Journal of Pharmaceutics, 552, (1-2), 2018, p27 - 38, Journal Article, PUBLISHED  DOI
Larkin CM, Hante NK, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia., PloS one, 2018, Journal Article, PUBLISHED  DOI
Inkielewicz-Stepniak I, Tajber L, Behan G, Zhang H, Radomski MW, Medina C, Santos-Martinez MJ, The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles, Materials, 11, (5), 2018, p1 - 12, Journal Article, PUBLISHED  DOI
Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology., Platelets, 29, (3), 2018, p301 - 304, Journal Article, PUBLISHED  DOI
Chan Guo Gin C; Lam C; Hante N; Keogh AP; Kelly B, Rozas I; Santos-Martinez MJ. , Effect of novel H2-receptor selective compounds on platelet aggregation, Pharmacology 2018, London, 18-20 December 2018, 2018, Meeting Abstract, PUBLISHED
Keogh AP; Hante N; Santos-Martinez MJ; Kelly B; Rozas I. , 4. Exploring the polypharmacology of 2-amino imidazoline derivatives: Antiaggregatory activity in human platelets, Medicinal Chemistry Ireland Conference 2018, Dublin City University, Dublin, Ireland, June , 2018, Meeting Abstract, PUBLISHED
Nam, L.; Coll, C.; Erthal, L.C.S.; de la Torre, C.; Serrano, D.; Martínez-Máñez, R.; Santos-Martínez, M.J.; Ruiz-Hernández, E., Drug delivery nanosystems for the localized treatment of glioblastoma multiforme, Materials, 11, (5), 2018, p779-, Review Article, PUBLISHED  DOI
Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Jurasz P, Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation., Cardiovascular research, 113, (14), 2017, p1719 - 1731, Journal Article, PUBLISHED  DOI
Mugheirbi N, Zotova J, Umerska AM, Santos-Martinez MJ, Tajber L. , Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, Meeting Abstract, PUBLISHED
  

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Mugheirbi N; Zotova J; Umerska AM; Santos-Martinez MJ; Tajber L, 2. Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, Meeting Abstract, PUBLISHED
Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prospects for some and training for all practicioners? , 2005, 17-19 , Report, PUBLISHED

  

Award Date
Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015
Innovation Award CRANN 2010
Catalan Respiratory Medicine Association (FUCAP) 2003
Catalan Respiratory Medicine Association (SOCAP) 2003
Spanish Respiratory Medicine Association (SEPAR) 2002
Dr Santos-Martinez research interests are focused on platelet biology and pharmacology; nanoparticle-cell and nanoparticle-platelet interactions (Nanotoxicology/Biocompatibility of nanomaterials) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and very sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating 1) the effect of different compounds, nanomaterials and novel formulations on platelet function and 2)the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).