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Dr. Maria Santos-Martinez

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW

 MariaJose.Santos@tcd.ie

 3531896 4281

Associate Professor (Clinical Medicine)


Biography

Dr Maria J Santos-Martinez is a medical doctor Specialist in Respiratory Medicine from the Universidad Autónoma de Barcelona (Spain). She started her training as basic researcher in The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth (University of Texas Health Science-Houston-USA) in 2004. In 2006 she moved to Ireland and defended her PhD in 2009 (Trinity College Dublin). She was appointed as Assistant Professor (Ussher) in Nanopharmaceutical Drug Discovery (School of Pharmacy and Pharmaceutical Sciences & School of Medicine) in 2010.

Research Tags

  ANGIOGENESIS   Blood Platelets   CANCER   MATRIX METALLOPROTEINASES   Nanomedicine   nanotoxicology   Pulmonary Diseases   QUARTZ CRYSTAL MICROBALANCE

Representations

Details Date
Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis

Languages

Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Spanish Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
COST Action 17140 'Cancer nanomedicine - from the bench to the bedside'(NANO2CLINIC) 2018 date
Irish Association of Pharmacologists (IAP) 2017 date
Member and co-founder of the Spanish Research Society in Ireland 2016 date
Spanish Respiratory Medicine Association (SEPAR) 2002 date
Kulkarni A, Bazou D, Santos-Martinez MJ., The role of Platelets in Multiple Myeloma, EACR-AACR Basic and Translational Research Conference: How to Bring Basic Science Discoveries to the Clinic, Dublin, 27-29/2/2024, 2024, Poster, PUBLISHED
Amelia Ultimo, Mar Orzaez, Maria J Santos-Martinez, Ramón Martínez-Máñez, María D Marcos, Félix Sancenón, Eduardo Ruiz-Hernández, High-capacity mesoporous silica nanocarriers of siRNA for applications in retinal delivery, International Journal of Molecular Sciences, 24, (3), 2023, p2753-, Journal Article, PUBLISHED  URL
McNamee N, Rodriguez de la Fuente L, Santos-Martinez MJ, O'Driscoll, Proteomics profiling identifies extracellular vesicles" cargo associated with tumour cell induced platelet aggregation, Cancer, 22, (1), 2022, p1023-, Notes: [doi: 10.1186/s12885-022-10068-7], Journal Article, PUBLISHED
Hajtuch J, Iwicka E, Szczoczarz A, Flis D, Megiel E, Cieciórski P, Radomski MW, Santos-Martinez MJ, Inkielewicz-Stepniak I, 3. The pharmacological effects of silver nanoparticles functionalized with eptifibatide on platelets and endothelial cells., International Journal of Nanomedicine, 17, 2022, p4383-, Notes: [doi: 10.2147/IJN.S373691], Journal Article, PUBLISHED
Menzel V, Ziegler M, Hante NK, Sake JA, Santos-Martinez MJ, Ehrhardt C, Kasper M, Barth K. , 4. Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis, European Journal of Pharmaceutical Sciences, 175, 2022, p106-, Notes: [doi: 10.3389/fphar.2021.733743], Journal Article, PUBLISHED
Hajtuch J, Santos-Martinez MJ, Wojcik M, Tomczyk E, Jaskiewicz M, Kamysz W, Narajczyk M, Inkielewicz-Stepniak I. , 5. Lipoic Acid-Coated Silver Nanoparticles: Biosafety Potential on the Vascular Microenvironment and Antibacterial Properties. , Frontiers Pharmacology, 2022, p733-, Journal Article, PUBLISHED
Amet R, Previtali V, Mihigo HB, Sheridan E, Brophy S, Hante NK, Santos-Martinez MJ, Hayden PJ, Browne PV, Rozas I, McElligott AM, Zisterer DM. , 6. A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma. , Life Sciences., 2022, Notes: [doi: 10.1016/j.lfs.2021.120236. ], Journal Article, PUBLISHED
Svenja Sladek, Fiona McCartney, Mena Eskander, David J. Dunne, Maria Jose Santos-Martinez, Federico Benetti, Lidia Tajber, David J. Brayden, An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer, Pharmaceutics, 12, (3), 2020, p259 , Journal Article, PUBLISHED
Smeaton T; McElwaine P; Cullen J; Santos-Martinez MJ; Deasy E; Widdowson M; Grimes T., A prospective observational pilot study of adverse drug reactions contributing to hospitalization in a cohort of middle-aged adults aged 45-64 years., Drugs & Therapy Perspectives , 36, 2020, p123 - 130, Journal Article, PUBLISHED  Other
Vasconcelos JM, Zen F, Angione MD, Cullen RJ, Santos-Martinez MJ, Colavita PE. , Understanding the Carbon-Bio Interface: Influence of Surface Chemistry and Buffer Composition on the Adsorption of Phospholipid Liposomes at Carbon Surfaces., ACS Applied Bio Materials., 3, (2), 2020, p997 - 1007, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

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Kulkarni A, Bazou D, Santos-Martinez MJ., Bleeding and Thrombosis in Multiple Myeloma: Platelets as Key Players during Cell Interactions and Potential Use as Drug Delivery Systems, International Journal of Molecular Sciences, 24, (21), 2023, p15855-, Notes: [doi: 10.3390/ijms242115855.], Journal Article, PUBLISHED
Anushka Kulkarni , Maria Jose Santos-Martinez , Despina Bazou, The role of platelets in multiple myeloma, Irish Association of Pharmacologists Annual Meeting, Cork, 3/11/2023, 2023, Oral Presentation, PUBLISHED
Maria J Santos-Martinez, 7th Pulmonary Drug Delivery Workshop, Dublin, 21/04/2022, 2022, Invited Talk, PUBLISHED
Gilmer JGF, Ryan F, Seoighe A, Santos-Martinez MJ, Ryan C, Ledwidge M., 7. Iron deficiency in Women of Childbearing Age with Self-reported Oral Iron Gastrointestinal Intolerance and Management with an oral Iron-Whey-Protein Formulation. , medRxiv, 2021, Report, PUBLISHED
Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prospects for some and training for all practicioners? , 2005, 17-19 , Report, PUBLISHED

  

Awards and Honours

Award Date
Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015
Innovation Award CRANN 2010
Catalan Respiratory Medicine Association (FUCAP) 2003
Catalan Respiratory Medicine Association (SOCAP) 2003
Spanish Respiratory Medicine Association (SEPAR) 2002

Research Interests

Description Of Research Interests

Dr Santos-Martinez research interests are focused on blood platelets biology and pharmacology; nanoparticle-cell and nanoparticle-blood platelets interactions (Nanotoxicology/Biocompatibility of nanomaterials) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and extremely sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating 1) the effect of different compounds, nanomaterials and novel formulations on platelet function and 2) the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).