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Professor Maeve Lowery

Prof. of Translational Cancer Medicine (Surgery)

 mlowery@tcd.ie

 


Biography

Professor Maeve Lowery is Professor of Translational Cancer Medicine at Trinity College Dublin and Consultant Medical Oncologist at St James Hospital. Professor Lowery is chairperson of the Cancer Molecular Diagnostics Advisory Group of the National Cancer Control Program (NCCP). Her clinical and translational research involves design and conduction of clinical trials in patients with gastrointestinal malignancies, incorporating translational study endpoints to validate predictive and prognostic biomarkers, identify mechanisms of resistance and guide the development of rational therapeutic strategies. Her translational research interests use of real time genomic profiling to identify novel therapeutic strategies for gastrointestinal cancers, identification of non coding alterations as modifiers of the DNA damage response pathway and generation of organoid models of cancer as a tool for precision oncology as a member of the PRECODE consortium. Her work is supported by the Pancreatic Cancer Research Fund (https://www.pcrf.org.uk), Science Foundation Ireland, through the Precision Oncology Ireland Consortium and the EU Horizon 2020 Marie Sklodowska-Curie Programme.

Research Tags

  ADVANCED GASTRIC-CANCER   ANTI-CANCER DRUG DESIGN   ANTICANCER DRUGS   CANCER   Cancer Biology   CANCER CHEMOTHERAPY   Cancer drug discovery   Cancer Genetics   Cancer Molecular Diagnostics   CANCER PATIENTS   CANCER TREATMENT   COLORECTAL CANCER   DNA-REPAIR   hereditary cancer   Immunotherapies for Cancer   Liver Cancer   ONCOGENES   PANCREATIC CANCER   TUMOR SUPPRESSOR GENES   tumour micro-enviroment
Varghese AM, Singh I, Singh R, Kunte S, Chou JF, Capanu M, Wong W, Lowery MA, Stadler ZK, Salo-Mullen E, Saadat LV, Wei AC, Reyngold M, Basturk O, O'Reilly EM, Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes., Journal of the National Cancer Institute, 2021, Journal Article, PUBLISHED
Donlon NE, Ravi N, King S, Cunninhgam M, Cuffe S, Lowery M, Wall C, Hughes N, Muldoon C, Ryan C, Moore J, O'Farrell C, Gorry C, Duff AM, Enright C, Reynolds JV, Modern oncological and operative outcomes in oesophageal cancer: the St. James's hospital experience., Irish journal of medical science, 2020, Journal Article, PUBLISHED
Power R, Lowery MA, Reynolds JV, Dunne MR, The Cancer-Immune Set Point in Oesophageal Cancer., Frontiers in oncology, 2020, Journal Article, PUBLISHED
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Zhu AX, Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study., The Lancet. Oncology, 2020, Journal Article, PUBLISHED
Maynard H, Stadler ZK, Berger MF, Solit DB, Ly M, Lowery MA, Mandelker D, Zhang L, Jordan E, El Dika I, Kemel Y, Ladanyi M, Robson ME, O'Reilly EM, Abou-Alfa GK, Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings., Cancer, 2020, Journal Article, PUBLISHED
O'Reilly EM, Lee JW, Zalupski M, Capanu M, Park J, Golan T, Tahover E, Lowery MA, Chou JF, Sahai V, Brenner R, Kindler HL, Yu KH, Zervoudakis A, Kelsen DP, Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline BRCA/PALB2 Mutation., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020, Journal Article, PUBLISHED
Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Kolch W, The future of genomics in Ireland " focus on genomics for health, 2020, Journal Article, PUBLISHED
Power R, Leavy C, Nolan C, White N, Clarke R, Cadoo KA, Gallagher DJ, Lowery MA, Prevalence of pancreaticobiliary cancers in Irish families with pathogenic BRCA1 and BRCA2 variants., Familial cancer, 2020, Journal Article, PUBLISHED
Lowery MA, Genotype-phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer., British journal of cancer, 2019, Journal Article, PUBLISHED
Cercek A, Boerner T, Tan BR, Chou JF, Gönen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Jarnagin WR, Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial., JAMA oncology, 2019, Journal Article, PUBLISHED
  

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