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Professor Mark Little

Professor/Consultant of Nephrology (Clinical Medicine)


  ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES   Biomarkers of disease   CRESCENTIC GLOMERULONEPHRITIS   IMMUNE-COMPLEX GLOMERULONEPHRITIS   Inflammation   MOUSE MODELS   Nephrology   NEUTROPHIL ADHESION   RAT MODEL   REGISTRY   SYSTEMIC VASCULITIS   VASCULITIS
 HELICAL - Health Data Linkage for Clinical Benefit
 AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
 Urinary sCD163 as a biomarker in crescentic glomerulonephritis
 Irish Rare Kidney Disease Registry and Biobank
 The acute, untreated patient with vasculitis: enhancing recruitment and sampling using a national network

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Details Date
Autoimmune strand lead, RITA European Reference Network 1/3/17
Co-chair UKIVAS national vasculitis registry 2010
Co-chair UKIVAS, the vasculitis rare disease group of the UK and Ireland 2011
Registries lead, European Vasculitis Society 2014
Chair Irish Rare Kidney Disease Registry and Biobank 2012
Chair of Irish Nephrology Society research committee 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Fellow of Trinity College Dublin 1/5/13
Fellow of the Royal College of Physicians 2012
American Society of Nephrology 2010
The Renal Association 2008
Lyons P.A., Peters J.E., Alberici F., Liley J., Coulson R.M.R., Astle W., Baldini C., Bonatti F., Cid M.C., Elding H., Emmi G., Epplen J., Guillevin L., Jayne D.R.W., Jiang T., Gunnarsson I., Lamprecht P., Leslie S., Little M.A., Martorana D., Moosig F., Neumann T., Ohlsson S., Quickert S., Ramirez G.A., Rewerska B., Schett G., Sinico R.A., Szczeklik W., Tesar V., Vukcevic D., Terrier B., Watts R.A., Vaglio A., Holle J.U., Wallace C., Smith K.G.C., Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status, Nature communications, 10, (1), 2019, p5120-, Journal Article, PUBLISHED  DOI
Dekkema GJ, Abdulahad WH, Bijma T, Moran SM, Ryan L, Little MA, Stegeman CA, Heeringa P, Sanders JF, Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019, p1039-1049 , Journal Article, PUBLISHED  DOI
Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Salama AD, A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis., Rheumatology (Oxford, England), 2019, p260-268 , Journal Article, PUBLISHED  DOI
Connaughton DM, Kennedy C, Shril S, Mann N, Murray SL, Williams PA, Conlon E, Nakayama M, van der Ven AT, Itself H, Kause F, Kolvenbach CM, Dai R, Vivante A, Braun DA, Schneider R, Kitzler TM, Moloney B, Moran CP, Smyth JS, Kennedy A, Benson K, Stapleton C, Denton M, Magee C, O'Seaghdha CM, Plant WD, Griffin MD, Awan A, Sweeney C, Mane SM, Lifton RP, Griffin B, Leavey S, Casserly L, de Freitas DG, Holian J, Dorman A, Doyle B, Lavin PJ, Little MA. Conlon PJ, Hildebrandt F., Monogenic causes of chronic kidney disease in adults, Kidney International, 95, (4), 2019, p914 - 928, Notes: [Kidney Int. 2019 Apr;95(4):914-928. doi: 10.1016/j.kint.2018.10.031.], Journal Article, PUBLISHED  DOI
Gopaluni, S. and Flossmann, O. and Little, M.A. and O'Hara, P. and Bekker, P. and Jayne, D., Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term Outcomes in Antineutrophil Cytoplasmic Antibodyâ€"Associated Vasculitis, Arthritis and Rheumatology, 71, (5), 2019, p784-791 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Pepper, R. and Jayne, D. and Little, M. and Pusey, C. and Salama, A.D., Comment on: A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis: Reply, Rheumatology (United Kingdom), 58, (4), 2019, p738-739 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Fazekas, B and Moreno-Olivera, A and Kelly, Y and O'Hara, P and Murray, S and Kennedy, A and Conlon, N and Scott, J and Melo, AM and Hickey, FB and Dooley, D and O'Brien, EC and Moran, S and Doherty, DG and Little, MA, Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury, Clinical and experimental immunology, 191, (2), 2018, p180â€"188 , Journal Article, PUBLISHED  DOI
Canney M, Sexton DJ, O'Leary N, Healy M, Kenny RA, Little MA, O'Seaghdha CM, Examining the utility of cystatin C as a confirmatory test of chronic kidney disease across the age range in middle-aged and older community-dwelling adults., Journal of epidemiology and community health, 72, 2018, p287-293 , Journal Article, PUBLISHED  URL
Ortiz-Fernández L, Carmona FD, López-Mejías R, González-Escribano MF, Lyons PA, Morgan AW, Sawalha AH, Smith KGC, González-Gay MA, Martín J, AAV Study group, Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis., Annals of the rheumatic diseases, 2018, Journal Article, PUBLISHED
O†Reilly, V.P. and Wong, L. and Kennedy, C. and Elliot, L.A. and O†Meachair, S. and Coughlan, A.M. and O†Brien, E.C. and Ryan, M.M. and Sandoval, D. and Connolly, E. and Dekkema, G.J. and Lau, J. and Abdulahad, W.H. and Sanders, J.-S.F. and Heeringa, P. and Buckley, C. and O†Brien, C. and Finn, S. and Cohen, C.D. and Lindemeyer, M.T. and Hickey, F.B. and O†Hara, P.V. and Feighery, C. and Moran, S.M. and Mellotte, G. and Clarkson, M.R. and Dorman, A.J. and Murray, P.T. and Little, M.A., Erratum: Urinary soluble CD163 in active renal vasculitis (Journal of the American Society of Nephrology (2016) 27 (2906-2916) DOI: 10.1681/ASN.2015050511), Journal of the American Society of Nephrology, 29, (8), 2018, p2255 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
  

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Award Date
President of Ireland Young Researchers Award 2012
I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. We are addressing the following questions: 1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis? 2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult? 3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.