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Dr. Joanne Lysaght

Associate Professor (Surgery)

Dr. Joanne Lysaght graduated with B.Sc.(Hons) in Science from N.U.I Maynooth. She then went on to complete a PhD in 2005, in the Department of Biochemistry and Immunology in Trinity College Dublin, in the area of Tumour Immunology. Following completion of her PhD, she moved to the Cancer Molecular Diagnostic Laboratory based in St. James's Hospital, which utilises molecular techniques for the diagnosis of haematological malignancies. She then took up a post-doctoral position in the Department of Haematology and Oncology, TCD, where she worked on a novel family of chemotherapeutic drugs for the treatment of childhood leukemias. Following on from this Dr. Lysaght moved to the Department of Surgery, TCD/St. James's Hospital. Her research focused on the role of the adaptive immune system in the link between obesity and gastrointestinal cancer. Based on this work she was awarded a competitive Health Research Board Post-Doctoral Fellowship. In 2011, Dr. Lysaght was appointed Ussher Assistant Professor in Molecular Oncology and in 2015 Assistant Professor in the School of Medicine, TCD where she continues her research into obesity and cancer. Other research areas of her group include targeting chemokines to prevent obesity-driven inflammation, examining the role of adaptive immunity in pre-malignant conditions, the impact of excess visceral adipose tissue on hepatic inflammation and identifying future immunotherapeutic targets for gastrointestinal cancers. Dr. Lysaght is also the course co-ordinator for the M.Sc. in Translational Oncology in TCD, designed for clinicians and scientists focused on a career in oncology and cancer research.
  ADIPOCYTES   ADIPOSE TISSUE   ADIPOSE-TISSUE DISTRIBUTION   ADJUVANT RADIOTHERAPY   ADVANCED CANCER   Anticancer therapies   Autoimmunity   BARRETTS ESOPHAGUS   CACHEXIA   Cancer Biology   CANCER BIOPSIES   CANCER CHEMOTHERAPY   CANCER CLASSIFICATION   CANCER DEVELOPMENT   CANCER PATIENTS   CANCER RISK   Cancer Therapy   Cancer/Carcinogenesis   CD4+ T CELLS   CHEMO-RADIOTHERAPY   COMBINATION IMMUNOTHERAPY   Design and evaluation of novel anti-cancer therapies   Development of novel neo-adjuvant treatments for oesophageal and prostate cancer   ESOPHAGEAL CANCER   GASTRIC CANCER   Gastrointestinal cancer   HUMAN ESOPHAGEAL CANCER   HUMAN T-CELLS   Immune system   Immunoassays   Immunology, Immunotherapy   Immunotherapies for Cancer   Innate immunology   METABOLIC DISORDERS   NK CELLS   OBESITY   Radiotherapy, Biological response modifiers and chemoprevention   Regulatory T cells   Sarcopenia   Tumour immunology and immunotherapy   TUMOUR IMMUNOTHERAPY
 Evaluating the role of T cells in the progression of Barrett's Oesophagus to Oesophageal Adenocarcinoma: identification of novel immunotherpeutic targets
 Investigating the role of T cells in adipose tissue and hepatic inflammation in obesity associated cancer.
 Investigating the immunomodulatory properties of adipose tissue in oesophageal and colorectal cancer.

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Irish Basic Basic Medium
Details Date From Date To
Treasurer and executive committee member for the Irish Society for Immunology 2014
Irish Association for Cancer Research 2011
European Association for Cancer Research 2011
European Federation of Immunological Societies 2014
Joanne Lysaght, The 'obesity paradox' in action with cancer immunotherapy, Nature Reviews Endocrinology, 2019, Notes: [DOI 10.1038/s41574-019-0161-2], Journal Article, PUBLISHED
MÃŒnch, N.S. and Fang, H.-Y. and Ingermann, J. and Maurer, H.C. and Anand, A. and Kellner, V. and Sahm, V. and Wiethaler, M. and Baumeister, T. and Wein, F. and EinwÀchter, H. and Bolze, F. and Klingenspor, M. and Haller, D. and Kavanagh, M. and Lysaght, J. and Friedman, R. and Dannenberg, A.J. and Pollak, M. and Holt, P.R. and Muthupalani, S. and Fox, J.G. and Whary, M.T. and Lee, Y. and Ren, T.Y. and Elliot, R. and Fitzgerald, R. and Steiger, K. and Schmid, R.M. and Wang, T.C. and Quante, M., High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome, Gastroenterology, 157, (2), 2019, p492-506.e2 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Lysaght, J., The â€~obesity paradox†in action with cancer immunotherapy, Nature Reviews Endocrinology, 15, (3), 2019, p132-133 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Lewis, D.E. and Lysaght, J. and Wu, H., Editorial: T cell alterations in adipose tissue during obesity, HIV, and cancer, Frontiers in Immunology, 10, (MAY), 2019, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Hannon, G. and Lysaght, J. and Liptrott, N.J. and Prina-Mello, A., Immunotoxicity Considerations for Next Generation Cancer Nanomedicines, Advanced Science, (1900133), 2019, Journal Article, PUBLISHED  TARA - Full Text  DOI
Kavanagh, M.E. and Conroy, M.J. and Clarke, N.E. and Gilmartin, N.T. and Feighery, R. and MacCarthy, F. and O†Toole, D. and Ravi, N. and Reynolds, J.V. and O†Sullivan, J. and Lysaght, J., Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma, Cancer Microenvironment, 2019, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Mongan AM, Lynam-Lennon N, Doyle SL, Casey R, Carr E, Cannon A, Conroy MJ, Pidgeon GP, Brennan L, Lysaght J, Reynolds JV, O'Sullivan J., Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma., International journal of medical sciences, 16, (4), 2019, p519-528 , Journal Article, PUBLISHED  TARA - Full Text  DOI
*Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238 , Notes: [*JOINT FIRST AUTHORSHIP], Journal Article, PUBLISHED  DOI  URL
O†Sullivan, J. and Lysaght, J. and Donohoe, C.L. and Reynolds, J.V., Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments, Nature Reviews Gastroenterology and Hepatology, 15, (11), 2018, p699-714 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J., Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients., Frontiers in immunology, 9, 2018, p1867 , Journal Article, PUBLISHED  TARA - Full Text  DOI

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Award Date
HRB Fellowship 2009
CROSS Research Fellowship 2008
Dr. Lysaght's research group focus on a number of different areas around the central theme of tumour immunology and immunotherapy. A major research interest is the area of obesity and cancer, and how this impacts anti-tumour immunity. The majority of research in the tumour immunology group is focused on upper gastrointestinal cancer, particularly oesophageal cancer. Research into how the regulation and trafficking of lymphocytes can be targeted to reduced adipose tissue and liver-associated inflammation is a major theme within the group. Other areas of interest include identifying novel immunotherapeutic targets in the pre-malignant setting such as Barrett's Oesophagus, which can be used to slow or prevent progression to malignancy. We are also currently investigating the impact of chemotherapy and radiotherapy on anti-tumour immunity and immunotherapies. Another area under current investigation is the role of adaptive immunity and obesity in the debilitating cancer-associated wasting disease cachexia and sarcopenia, which is directly responsible for up to 20% of all cancer deaths.