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Dr. Helen Sheridan

Associate Professor (Pharmacy)

Dr Helen Sheridan; was educated in St. Paul's Secondary School in Greenhills Dublin - where her passion for science was fuelled by her inspirational teachers Sr. Elizabeth Walsh and Mr. Edward Mc. Donald. She completed her Ph. D in University College Dublin under another inspirational figure Professor DMX Donnelly. Helen was awarded a 'Royal Commission for the Exhibition of 1851' Overseas Fellowship for Postdoctoral research which was carried out at the Dyson Perrins laboratories at Oxford University under the direction of Professor Sir Jack Baldwin. Following further research periods at University College Dublin and the CNRS at Gif-sur-Yvette she was appointed as a lecturer in Natural Products Chemistry to the Department of Pharmacognosy, School of Pharmacy in Trinity College Dublin in 1985. She was appointed advisor to the 'National Drugs Advisory Board', now the 'The Irish Medicines Board' in 2000 and currently serves on the Traditional Herbal Medicinal sub-committee. She has undertaken original research in traditional medicine and development of new medicines using plants and cell cultures (plant, fungal and animal) for which she has received state funding. She has received funding (€12M) to support the development of novel anti-inflammatory and immunomodulatory compounds which are the subject of a number of patents. She is part of an international Sino-European consortium working to promote and support networking and coordination of research activities applying functional genomics in the context of Traditional Chinese Medicine (TCM). The consortium was awarded funding through EU-FP7 (co-ordination grant). Dr. Sheridan is Director of research at the School of Pharmacy and Pharmaceutical Sciences. She is Co-founder of Trino Therapeutics Ltd (formerly Pharmatrin Ltd.) a TCD campus company. Principal investors the Wellcome Trust, VC's and Enterprise Ireland.
  ALTERNATIVE MEDICINE   Antiinflammatory drugs   Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Biotransformation   Chemical Biology   Development of drugs for malaria, Cancer and inflammatory diseases   Drug discovery   Fungi   Herbal medicine   In Vitro Testing, Trial Methods   Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants   Inflammation   Inflammatory Bowel Disease   Medicinal plants   Multiple Sclerosis   Natural Product Chemistry   Organic chemistry   Over-the-Counter Drugs   Pharmacognosy   Phytochemical and pharmacological evaluations of native and foreign plants   Phytomedicines   Plant and algal cell monocultures   Secondary plant metabolism   The use of cell cultures for the discovery of novel drugs   Traditional and Indigenous health systems in developing countries   Traditional Chinese Medicine
 Novel indanes as potential therapies for auto-immune disease
 Investigation into Mechanism of action of PH46A
 A novel indane scaffold with potential anti-inflammatory agents.
  Traditional Chinese medicine research in the post-genomic era: Good practice,priorities, challenges and opportunities
 Effect of novel indanes on mast cell function

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Details Date
Appointed to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date
Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2003 - 2006
Appointed external examiner to taught postgraduate masters programmes at the School of Pharmacy. University College London. 2014-2017
Youth Science committee of the Royal Dublin Society 1990-1992
International Foundation for Science Grant reviewer 2009 to date
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
Cumming, Graham; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen, Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-Inflammatory Agent , Organic Process Research & Development, 2018, p1972-1979 , Journal Article, PUBLISHED  DOI
Tao Zhang, Neil Frankish, Gaia Scalabrino and Helen Sheridan, Bioactive Indanes: Comparative in vitro Metabolism Study of PH46A, a New Potential Anti-Inflammatory Agent and Biosynthesis of its Primary Metabolite PH132 Pharmaceutical Sciences, Pharmaceutical Sciences, 2018, Journal Article, IN_PRESS
Tao Zhang , Gaia Scalabrino , Neil Frankish and Helen Sheridan, "Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent" , Molecules, 23 , 2018, p1 - 18, Journal Article, PUBLISHED  DOI
Hook I, Sheridan, H, Reid C, Trichomes and naphthoquinones protect Streptocarpus dunnii Hook.f. against environmental stresses, South African Journal of Botany , Volume 119, 2018, p193 - 202, Journal Article, PUBLISHED
Zhang, T. and Scalabrino, G. and Frankish, N. and Sheridan, H., Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent, Molecules, 23, (7), 2018, p1503-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Frankish, N.H. and McHale, B. and Sheridan, H., The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Journal of Pharmacy and Pharmacology, 70, (1), 2018, p101-110 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Grace, C. and Boland, T.M. and Sheridan, H. and Lott, S. and Brennan, E. and Fritch, R. and Lynch, M.B., The effect of increasing pasture species on herbage production, chemical composition and utilization under intensive sheep grazing, Grass and Forage Science, 2018, Notes: [cited By 0; Article in Press], Journal Article, PUBLISHED  DOI
History and current status of Herbal Medicines' in, editor(s): Heikki Vuorela, Pierre Duez, Pia Maarit Vuorela, and Olavi Pelkonen. , Toxicology of Herbal Products, Springer Science and Business Media, 2017, [2. Sendker J and Sheridan H: ], Book Chapter, PUBLISHED  URL
Composition and quality control of herbal medicines in, editor(s)Heikki Vuorela, Pierre Duez, Pia Maarit Vuorela, and Olavi Pelkonen , Toxicology of Herbal Products', Springer Science & Business Media. , 2017, [3. Sendker J and Sheridan H], Book Chapter, PUBLISHED  URL
Frankish, Neil; McHale, Brendan; Sheridan, Helen,, The indane diastereoisomers, PH2 and PH5: divergence between their effects in DTH models and a model of colitis" by F, Journal of Pharmacy and Pharmacology, 70, (1), 2017, p101-110 , Journal Article, PUBLISHED  DOI

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Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017, Conference Paper, PUBLISHED
Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017, Report, PUBLISHED
Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1-, Conference Paper, PUBLISHED
Helen Sheridan and Ciara Smyth, Identification of extracts (and compounds) that could be derived from new plant species, grown in Ireland. An overview of species, market and potential partners who have processing experience, Enterprise ireland 1V-2012-3242., 2014, Report, PUBLISHED
Nazir, I., Rahman, N., Chan, K., Frankish, N., Sheridan, H, Ethnobotanical Study of Antidiabetic Plants of Cholistan Desert, District Bahawalpur, Pakistan, London BioNat, University of East London. UK, March 12th 2013., 2013, Poster, PUBLISHED
Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu , Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission., 2011/10/17, 2011, Dataset, PUBLISHED
E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9 , Meeting Abstract, PUBLISHED
Hook, I., Comey, N. & Sheridan, H., Phytochemical evaluation of roots from cultivated L alpinum, Irish Botanists Meeting, University College Dublin, 2001, Notes: [ ], Conference Paper, PRESENTED
Hook, I., Comey, N. & Sheridan, H., Effect of inulin as carbon source on growth and essential oil content of Edelweiss hairy roots, 27th International Symposium on Essential Oils, Vienna, Austria, 1996, Conference Paper, PRESENTED
Hook, I., Comey, N., James, P. & Sheridan, H., A 2,3- dihydrochromone from the essential oil of edelweiss, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1994, Notes: [ ], Conference Paper, PRESENTED


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Award Date
Department of Education Post Doctoral Fellowship (UCD). 1984-1985
"1851 Overseas Traveling Scholarship". 1983-1984
French Government research Award - CNRS. Gif-Sur-Yvette 1983
NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979
RIA Travelling award 1990
Travel awards: British Council 1991
Wellcome Trust Strategic Translation Award (co-PI) 2013
SFI TIDA Award 2017
My research has always been multidisciplinary built on collaboration with pharmacologists, molecular biologists, biotechnologists and botanists, and is recognised at a national and inter-national level. I believe interdisciplinary research is the key requirement for Novel Drug Discovery, where a range of expertise is required to bring therapeutic discoveries from concept to execution. My post-graduate students have benefitted from this approach, learning early in the process, to work in a team with joint, or multiple supervisors, at the interface of many areas of expertise. I am not afraid to lead in this area, and believe that multi-component therapeutics from natural sources will be in use clinically, globally, in my lifetime. This is why I have engaged with the International, Multidisciplinary TCM Consortium establishing good practice (GP-TCM) and gold standards for quality, safety and efficacy of these complex medicines, as determined by 2004/24/EC. Ireland and TCD need to be involved in the critical mass of this complex Drug Discovery platform. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. Due to my research led teaching in Natural Products Chemistry, the interdisciplinary nature of this area is constantly underlined at all levels. . Multidisciplinary approach to drug discovery and development. . The use of plants and cell cultures (plant, fungal and animal), for the discovery of novel bio-active materials. . Preparation of novel anti-inflammatory, anticancer, and immunomodulatory compounds by chemical and biological means. . Traditional Chinese Medicine (TCM). Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Chinese Medicine. . Traditional Herbal Medicines. Collaborative analysis of Bioactive Brazilian and Pakastini plant species. . Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. . Finding new therapies targeted at diseases with unmet clinical need. . Drug discovery from the natural world, inspired by Ethnopharmacology . Drug discovery and optimised production:- plants; fungi; marine species. Use of biotechnology to modify biosynthesis and to generate biomass . Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. . Global health in a Development context: Impact on Health. (Rwanda, Malawi, Kenya).